Results 11 to 20 of about 745,895 (231)

Boosted Tidal Disruption by Massive Black Hole Binaries During Galaxy Mergers FROM The View of N-Body Simulation [PDF]

open access: yes, 2016
Supermassive black hole binaries (SMBHBs) are productions of the hierarchical galaxy formation model. There are many close connections between central SMBH and its host galaxy because the former plays very important roles on the formation and evolution ...
Berczik, Peter   +3 more
core   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Evolution of the surface magnetic field of rotating proto-neutron stars

open access: yes, 2017
We study the evolution of the field on the surface of proto-neutron stars in the immediate aftermath of stellar core collapse by analyzing the results of self-consistent, axisymmetric simulations of the cores of rapidly rotating high-mass stars.
Aloy, Miguel-Ángel   +1 more
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

West Irondequoit Central School District and West Irondequoit Teachers Association [PDF]

open access: yes, 2014
In the matter of the fact-finding between the West Irondequoit Central School District, employer, and the West Irondequoit Teachers Association, union. PERB case no. M2013-095. Before: Stephen P.
LaLonde, Stephen P
core   +1 more source

Enhanced accretion rates of stars on Super-massive Black Holes by star-disk interactions in galactic nuclei

open access: yes, 2012
We investigate the dynamical interaction of a central star cluster surrounding a super-massive black hole and a central accretion disk. The dissipative force acting on stars in the disk leads to an enhanced mass flow towards the super-massive black hole ...
Andreas Just   +33 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Coastal Blue Carbon Opportunity Assessment for Snohomish Estuary: The Climate Benefits of Estuary Restoration [PDF]

open access: yes, 2014
This report presents the findings of a groundbreaking study that confirms the climate mitigation benefits of restoring tidal wetland habitat in the Snohomish Estuary, located within the nation's second largest estuary: Puget Sound.
Danielle L. Devier   +5 more
core  

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