Results 61 to 70 of about 44,954 (307)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Modeling of Ice Accretion over Aircraft Wings Using a Compressible OpenFOAM Solver
International Journal of Aerospace Engineering, 2019 A method to simulate ice accretion on an aircraft wing using a three-dimensional compressible Navier-Stokes solver, a Eulerian droplet flow field model, a mesh morphing model, and a thermodynamic model, is presented in this paper.
Sibo Li, Roberto Paoli
doaj +1 more source
Inception of ice accretion by ice crystal impact [PDF]
Journal of Physics: Conference Series, 2016 In this experimental and theoretical study the ice accretion phenomena on a heated cylinder in Braunschweig Icing Wind Tunnel are investigated. The ice crystal size, velocity, the liquid-to-total mass ratio are accurately controlled. The evolution of the cylinder temperature, the time required for the inception of the ice accretion, and the ice ...
Jens Löwe +5 more
openaire +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Aerodynamic Performance Losses due to Ice Formation on the UAV’s Wings
Havacılık ve Uzay Teknolojileri Dergisi, 2020 Ice accretion on unmanned air vehicle’s wing modifies the initial airfoil contour and changes the aerodynamic characteristic of the wing. The aim of this research is to calculate performance losses on a wing due to the accretion of rime ice.
Durmus Sinan Körpe +2 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
AerospaceA scientific balloon is the ideal platform for carrying out long-duration missions for scientific research in the stratosphere. However, when a scientific balloon ascends through icy clouds and reaches supercooled droplets, there is a risk of ice ...
Qiang Liu +6 more
doaj +1 more source
Quantification of ice accretions for icing scaling evaluations [PDF]
36th AIAA Aerospace Sciences Meeting and Exhibit, 1998 The comparison of ice accretion characteristics is an integral part of aircraft icing research. It is often necessary to compare an ice accretion obtained from a flight test or numerical simulation to one produced in an icing wind tunnel or for validation of an icing scaling method.
Gary Ruff, David Anderson
openaire +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
南方能源建设[Objective] Ice accretion on transmission lines is one of the common extreme meteorological risks in power systems. To enhance the safe operation of transmission lines, this study addresses key technical issues in ice accretion prediction and monitoring.
Hongliang ZHOU +7 more
doaj +1 more source