Results 81 to 90 of about 44,954 (307)

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

A Rapid Prediction Model of Three-Dimensional Ice Accretion on Rotorcraft in Hover Flight

Aerospace
Helicopters often operate at altitudes where cloud activity is prevalent, making them susceptible to icing hazards. Accurate and rapid prediction of ice accretion on rotors is crucial for expanding helicopter flight capabilities and enhancing flight ...
Weibin Li, Fan Liu, Dazhi Zhao, Xingda Cui, Zhongyun Xiao, Kaicheng Li   +5 more
doaj   +1 more source

Accretion and photodesorption of CO ice as a function of the incident angle of deposition [PDF]

, 2019
Non-thermal desorption of inter- and circum-stellar ice mantles on dust grains, in particular ultraviolet photon-induced desorption, has gained importance in recent years.
Aparicio, S., Carrascosa de Lucas, H., Cazaux, S., Chen, Y.-J., González Díaz, C., Hsiao, L.-C., Munoz Caro, G.M., Sie, N.-E.   +7 more
core   +3 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Advancements in the LEWICE Ice Accretion Model [PDF]

Recent evidence has shown that the NASA/Lewis Ice Accretion Model, LEWICE, does not predict accurate ice shapes for certain glaze ice conditions.
Wright, William B.
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Review of Icing Effects on Wind Turbine in Cold Regions

E3S Web of Conferences, 2018
This paper describes a brief overview of main issues related to atmospheric ice accretion on wind turbines installed in cold climate region. Icing has significant effects on wind turbine performance particularly from aerodynamic and structural integrity ...
Afzal Faizan, Virk Muhammad S.
doaj   +1 more source

Numerical simulation of ice growth on a MS-317 swept wing geometry [PDF]

An effort to develop a 3-D ice accretion modeling method was initiated. This first step towards creation of a complete aircraft icing simulation code builds on previously developed methods for calculating 3-D flow fields and particle trajectories ...
Bidwell, C. S., Potapczuk, M. G.
core   +1 more source