Results 71 to 80 of about 44,954 (307)

Experimental approach and initial forest response to a simulated ice storm experiment in a northern hardwood forest.

PLoS ONE, 2020
Ice storms are a type of extreme winter weather event common to north temperate and boreal forests worldwide. Recent climate modelling studies suggest that these storms may become more frequent and severe under a changing climate. Compared to other types
Lindsey E Rustad, John L Campbell, Charles T Driscoll, Timothy J Fahey, Peter M Groffman, Paul G Schaberg, Gary J Hawley, Ian Halm, Frank Bowles, Wendy Leuenberger, Geoffrey Schwaner, Gabriel Winant, Brendan Leonardi   +12 more
doaj   +1 more source

A Numerical Ice-Accretion Model [PDF]

Journal of Glaciology, 1977
AbstractA numerical model is developed for calculating the rate and total amount of ice accretion under atmospheric conditions. The principal application of the numerical approach is to aircraft icing and more specifically, helicopter icing problems. These problems are best solved using numerical techniques because of three factors: (1) the dependence ...
openaire   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Surrogate modelling for ice accretion prediction on wind turbine blades based on support vector regression

IET Renewable Power Generation
Ice accretion poses a significant challenge, threatening the safety and operational stability of wind turbines in extreme cold weather. Accurate estimation of ice accretion is essential in minimizing this concern. Data‐driven techniques typically rely on
Shouyuan Mao, Yangyang Wu, Liheng Zhao, Weike Mo   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Heat transfer on accreting ice surfaces [PDF]

Based on previous observations of glaze ice accretion on aircraft surfaces, a multizone model with distinct zones of different surface roughness is demonstrated. The use of surface roughness in the LEWICE ice accretion prediction code is examined. It was
Hansman, R. John, Jr., Yamaguchi, Keiko
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Ice Accretion in Freezing Rain. [PDF]

, 1996
Abstract : Ice accreted on structures from freezing rain causes both increased vertical loads and increased wind loads, due to the larger projected area of the structure. Structural failures initiated by ice loads frequently cause millions of dollars of damage to overhead power and communication lines, towers, and other ice-sensitive structures.
openaire   +1 more source

Ice Accretion Prediction for a Typical Commercial Transport Aircraft [PDF]

Ice accretion calculations were made for a modern commercial transport using the NASA Lewis LEWICE3D ice accretion code. The ice accretion calculations were made for the wing and horizontal tail using both isolated flow models and flow models ...
Bidwell, C. S.
core   +1 more source