Results 31 to 40 of about 1,573,418 (267)

A Low-Cost Humidity Control System to Protect Microscopes in a Tropical Climate

Annals of Global Health, 2020
Introduction: A clean and functional microscope is necessary for accurate diagnosis of infectious diseases. In tropical climates, high humidity levels and improper storage conditions allow for the accumulation of debris and fungus on the optical ...
Anders J. Asp, Christina M. Webber, Evan N. Nicolai, Gabriel Martínez-Gálvez, Victoria S. Marks, Ephraim I. Ben-Abraham, John W. Willson, J. Luis Luján   +7 more
doaj   +1 more source

Effects of thermal and pressure loads on structural deformation of liquid oxygen/methane engine combustion chamber

Journal of Thermal Science and Technology, 2020
To investigate the influences of thermal and pressure loads on the structural deformation of the Liquid Oxygen/Methane rocket engine combustion chamber, a complete thermo-structural analysis scheme including fluid-thermal analysis and structural finite ...
Di LIU, Bing SUN, Jiawen SONG, Taiping WANG, Xingyu MA   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Mechanism analysis of rock damage and failure based on the relation between deep chamber axial variation and in situ stress fields

工程科学学报, 2022
The demands for deep underground mining and construction are increasing with the continuing development of society and the economy. Deep underground chambers function as primary elements in deep underground mining and other subsurface facilities ...
Li-yuan LIU, Le ZHANG, Hong-guang JI
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigation of intra-day variability of gaseous measurements in sheep using portable accumulation chambers

Journal of Animal Science, 2021
Abstract Portable accumulation chambers (PAC) enable short-term spot measurements of gaseous emissions including methane (CH4), carbon dioxide (CO2), and oxygen (O2) consumption from small ruminants. To date the differences in morning and evening gaseous measurements in the PAC have not been investigated.
O’ Connor, Edel, McHugh, Nóirín, Boland, Tommy M, Dunne, Eoin, McGovern, Fiona M   +4 more
openaire   +3 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Developing a reference method for indirect measurement of pasture evapotranspiration at sub-meter spatial resolution

Smart Agricultural Technology
To establish an indirect method for estimating and partitioning pasture evapotranspiration, it is vital to develop a direct reference method that aligns with the required temporal and spatial resolution.
Muhammad Shahinur Alam, David William Lamb, Muhammad Moshiur Rahman, Marcus Randall   +3 more
doaj   +1 more source

Constraints on magma storage conditions based on geodetic volume change and erupted magma volume and application to the 2011 and 2018 eruptions at Kirishima Shinmoe-dake volcano, Japan

Earth, Planets and Space, 2023
We investigated magma storage conditions prior to the 2011 and 2018 eruptions at Kirishima Shinmoe-dake volcano in Japan based on the relationship between geodetic volume change of magma chamber and erupted magma volume.
Tomofumi Kozono, Takehiro Koyaguchi, Hideki Ueda, Taku Ozawa, Tadashi Yamasaki   +4 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source