Results 51 to 60 of about 1,573,418 (267)

Research on Oil–Gas Two-Phase Flow Characteristics and Improvement of Aero-Engine Bearing Chamber

Lubricants, 2023
In order to study the oil–gas two-phase flow characteristics of an aero-engine bearing chamber and improve the scavenge effect of lubricating oil, the two-phase flow solution model of a bearing chamber based on the Euler–Euler method was established ...
Guozhe Ren, Yanpeng Li, Huan Zhao, Yang Yan, Wenfeng Xu, Dan Sun   +5 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A Study on the Development of Real-Time Chamber Contamination Diagnosis Sensors

Sensors
Plasma processes are critical for achieving precise device fabrication in semiconductor manufacturing. However, polymer accumulation during processes like plasma etching can cause chamber contamination, adversely affecting plasma characteristics and ...
Junyeob Lee, Kyongnam Kim
doaj   +1 more source

Development and evaluation of an inhalation chamber for in vivo tests

Anais da Academia Brasileira de Ciências, 2017
The bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization.
EDUARDO R. DA SILVA, HUMBERTO R. BIZZO, PATRÍCIA D. FERNANDES, VALDIR F. DA VEIGA JUNIOR, SUZANA G. LEITÃO, DANILO R. DE OLIVEIRA   +5 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Research on the method to measure the average radon exhalation rate of room inner surface

Nuclear Engineering and Technology
In high-rise buildings, radon from building materials is one of the main sources of indoor radon. People spend an average of 80 % of their time indoors every day.
Hongbo Xu, Fen Lin, Shuaibin Liu, Huiying Li, Zhongkai Fan, Ruomei Xie, Xinyue Yang, Xianfa Mao, Shicheng Luo, Chenxi Zu, Feng Xiao, Jia Liu, Yi Liu, Haoyu You, Hao You, Cheng Luo, Hongzhi Yuan, Yanliang Tan   +17 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Assessment of geogenic radon potential with activation of advective soil air flow

Радиационная гигиена
Prediction of radon potential and justification of measures for reducing radon concentration in buildings necessitate the study of soil radon transport.
I. V. Yarmoshenko, G. P. Malinovsky, I. A. Yurkov, V. S. Izgagin   +3 more
doaj   +1 more source

Huntsville Chamber of Commerce Correspondence

, 2019
Questionnaire sent to Huntsville Chamber of Commerce ...
Huntsville Chamber of Commerce
core   +3 more sources