Results 121 to 130 of about 1,349,968 (301)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Incremental Forming of Polymeric Sheet Printed by Fused Deposition Modeling [PDF]

open access: yesInternational Journal of Advanced Design and Manufacturing Technology, 2019
Single point incremental forming (SPIF) and fused deposition modeling 3D printing (FDM) are two methods of rapid prototyping. Each method has its own pros and cons.
Saeid Esmaeili   +2 more
doaj  

On the formation time scale of massive cluster ellipticals based on deep near-IR spectroscopy at z~2

open access: yes, 2013
We present improved constraints on the formation time scale of massive cluster galaxies based on rest-frame optical spectra of galaxies in a forming cluster located at z=2.16.
De Breuck, Carlos   +8 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

A General Accurate Current Limiting Strategy of Grid-Forming Converters Based on Adaptive Virtual Impedance Regulated by Fuzzy Control

open access: yesIEEE Open Journal of Power Electronics
Grid-forming (GFM) converters are considered as a key solution for new power system with high penetration of renewable energy resources, owing to its voltage and frequency support ability.
Xinyu Liu, Qi Jia, Jia Liu, Jinjun Liu
doaj   +1 more source

On the Fractal Distribution of HII Regions in Disk Galaxies

open access: yes, 2008
In this work we quantify the degree to which star-forming events are clumped. We apply a precise and accurate technique to calculate the correlation dimension Dc of the distribution of HII regions in a sample of disk galaxies.
Alfaro, Emilio J., Sanchez, Nestor
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

The MOSDEF Survey: Excitation Properties of $z\sim 2.3$ Star-forming Galaxies

open access: yes, 2015
We present results on the excitation properties of z~2.3 galaxies using early observations from the MOSFIRE Deep Evolution Field (MOSDEF) Survey.
Coil, Alison L.   +10 more
core   +1 more source

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