Results 91 to 100 of about 1,055,963 (241)

活性炭与树脂对芝麻ACE抑制肽脱苦的工艺优化 及其性能比较Optimization of debittering of sesame ACE inhibitory peptide by activated carbon and resin and their performance comparison

Zhongguo youzhi
为改善芝麻ACE抑制肽的味道，分别采用活性炭与树脂对芝麻ACE抑制肽进行脱苦，以脱苦率、多肽损失率为评价指标，采用单因素实验和正交实验对两种脱苦工艺条件进行优化，并比较两种脱苦方法对芝麻ACE抑制肽味觉特性、活性及氨基酸组成的影响，以确定最适宜的脱苦方法。结果表明：两种方法均能使芝麻ACE抑制肽液苦味降至无法察觉，活性炭脱苦最佳工艺条件为活性炭2号添加量6%、芝麻ACE抑制肽液质量浓度10 g/100 mL、吸附温度55 ℃、吸附时间15 min，在此条件下脱苦率与多肽损失率分别为（96.46±0.57）
芦鑫1,2，游静1,2，金璐1,2，宋国辉1,2，孙强1,2，黄纪念1,2,3LU Xin1,2, YOU Jing1,2, JIN Lu1,2, SONG Guohui1,2, SUN Qiang1,2, HUANG Jinian1,2,3
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mining anti-hypertensive peptides in animal food through deep learning: a case study of gastrointestinal digestive products of royal jelly

Food Science of Animal Products
To shorten the complex and time-consuming process of the identification method of the traditional food angiotensin-I-converting enzyme (ACE-I) inhibitory peptides, we propose AHTPeptideFusion based on a segmented fusion with the protein language model ...
Fei Pan, Dongliang Liu, Tuohetisayipu Tuersuntuoheti, Huadong Xing, Zehui Zhu, Yu Fang, Lei Zhao, Liang Zhao, Xiangxin Li, Yingying Le, Qiannan Hu, Wenjun Peng, Wenli Tian   +12 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

ACE-inhibitory effect of the RP-HPLC fractions and IEF sub-fractions.

, 2019
ACE-inhibitory effect of the RP-HPLC fractions and IEF sub-fractions.
Shehu Muhammad Auwal (6755777), Chin Ping Tan (1974856), Mohammad Zarei (6755783), Nazamid Saari (762896), Najib Zainal Abidin (6755780)   +4 more
core   +1 more source

Preparation and Antihypertensive Effect of Microcapsules Containing Medicinal and Culinary Plant Materials and Angiotensin Converting Enzyme Inhibitory Peptide [PDF]

Shipin Kexue
In this study, the antihypertensive effect of microcapsules containing a mixture of goji berry, hawthorn and cassia seed at a mass ratio of 4:1:1 and angiotensin converting enzyme (ACE) inhibitory peptide in spontaneously hypertensive rats (SHR) was ...
XIA Yu, LI Xiaodong, LIU Lu, ZHOU Wenli, JIA Zhibin, JIAO Yang, XIE Qinggang
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Long-Term Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory Peptide LAP

, 2011
<i>Objective:</i> To study the antihypertensive effects of the angiotensin-converting enzyme (ACE)-inhibitory peptide LAP on blood pressure in spontaneously hypertensive rats (SHRs).
Zhanxia Li, Hong Fang, Huan Zheng, Junlin Huang, Liu Chi, Yuqing Deng, Luo Ming, Shen Yi, Lingxia Li   +8 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source