Results 231 to 240 of about 132,338 (329)

AT1R in Central Nervous System Disorders: Unveiling Novel Mechanisms and Therapeutic Avenues for Addiction

Addiction Biology, Volume 31, Issue 4, April 2026.
AT1R signaling drives addiction through interconnected pathways, and AT1R antagonists target multiple nodes for therapeutic effects. ABSTRACT Although the angiotensin II type 1 receptor (AT1R), a pivotal component of the renin–angiotensin system (RAS), is associated with cardiovascular and renal homeostasis, burgeoning evidence implicates its critical ...
Jianan Lv, Dan Zhu, Sisi Song, Jiahui Zhou, Xiaoyu Zhang, Wenhua Zhou, Yu Liu, Zizhen Si   +7 more
wiley   +1 more source

Hyperglycemia-Induced Endothelial Dysfunction: From Classical Pathogenetic Mechanisms to Emerging Insights into ACE2 Protective Action. [PDF]

Int J Mol Sci
Lodi G, Sergi D, Dipinto A, Bompan F, Secchiero P, Voltan R, Romani A.   +6 more
europepmc   +1 more source

Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence—The Protective Effect of Valsartan

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Calcineurin inhibitors (CNI) such as tacrolimus (Tac) are the first‐line treatment to prevent transplant rejection. However, CNI have adverse effects on blood vessels and renal function, which may be linked to cellular senescence. Valsartan, a common angiotensin II type 1 receptor (AT1R) blocker, exhibits anti‐senescence properties.
Lingyan Fei, Xiaohua Wang, Lingyi Kong, Tianjiao Cui, Pratik H. Khedkar, Yunxiu Xiang, Dongliang Zhao, Junxuan Fang, Yulin Liang, Yangyang Zhang, Nan Xu, Xingyu Qiu, Liang Zhao, Gensheng Zhang, Yan Lei, Chun Tang, Kongyang Ma, Liwei Lu, Jin Wei, En Yin Lai, Pontus B. Persson, Andreas Patzak, Zhihua Zheng, Shan Jiang   +23 more
wiley   +1 more source

Evaluation of molecular interactions of vaping juice components with ACE2 receptor. [PDF]

Sci Rep
Mallawarachchi S, Nangia A, Ibrahim MJ, Haq A, Fernando S, King MD.   +5 more
europepmc   +1 more source

α‐Mangostin Attenuates Blood Pressure and Reverses Vascular Remodeling by Balancing ACE/AT1R and ACE2/Ang‐(1–7)/MasR Axes in Ang II‐Infused Hypertensive Mice [PDF]

Qiqi Xue, Chu‐Hao Liu, Dong‐Yan Zhang, Ming‐Xuan Li, Yan Li   +4 more
openalex   +1 more source

Angiotensin‐(1–7) Alleviates Isoproterenol‐Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin II Type 2 Receptor

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim The aim of this study is to determine whether Angiotensin‐(1–7) [Ang‐(1–7)] alleviates isoproterenol (ISO)–induced cardiac hypertrophy by suppressing excessive autophagy and apoptosis through coordinated Mas receptor (MasR) and angiotensin II type‐2 receptor (AT2R) signaling, and to elucidate the underlying mechanisms.
Xiaomei Wang, Fei Guo, Xiaoqian Wang, Yu Guo, Siyao Fan, Lan Hong, Honghua Jin   +6 more
wiley   +1 more source

Structural basis for bat receptor recognition by SARS-CoV-2 and bat SARS2-like coronaviruses. [PDF]

Commun Biol
Hsueh FC, Shi K, Aihara H, Li F.
europepmc   +1 more source

Prevalence of new‐onset diabetes following COVID‐19 infection: A systematic review and meta‐analysis

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3182-3192, April 2026.
Abstract Aim To estimate the prevalence of new‐onset diabetes in adults (≥ 18 years) following SARS‐CoV‐2 infection. Materials and Methods This meta‐analysis includes studies written in English that measured the number of adults (≥ 18 years) diagnosed with diabetes following SARS‐CoV‐2 infection.
Jordan N. Keels, Rose D. LaPlante, Christopher S. Lee, Andrew A. Dwyer   +3 more
wiley   +1 more source

Reduced COVID-19 severity in Africa: a systematic review of host genetic and immunological responses to SARS-CoV-2 infection. [PDF]

Front Immunol
Manu GP, Bonney JHK, Bawa FK, Quashie PK, Kusi KA, Amoah LE.   +5 more
europepmc   +1 more source

Molecular optimization, docking, and dynamic simulation profiling of selective aromatic phytochemical ligands in blocking the SARS-CoV-2 S protein attachment to ACE2 receptor: an in silico approach of targeted drug designing

, 2021
Dipta Dey, Parag Kumar Paul, Salauddin Al Azad, Mohammad Faysal Al Mazid, Arman Mahmud Khan, Md. Arman Sharif, Md. Hafijur Rahman   +6 more
openalex   +1 more source