Results 241 to 250 of about 132,338 (329)

Effects of sotagliflozin on markers of volume status and sodium handling in patients with type 1 diabetes: A biomarker analysis of the inTandem3 clinical trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3254-3263, April 2026.
Abstract Aims Sotagliflozin, an inhibitor of sodium‐glucose co‐transporter (SGLT)‐1 and 2, reduces albuminuria, slows GFR decline, and may have diuretic and osmoregulatory effects. The effect of sotagliflozin added to insulin was assessed on markers of neurohormone activation and volume homeostasis in patients with type 1 diabetes (T1D).
Massimo Nardone, Erik Moedt, Hiddo J. L. Heerspink, Michael J. Davies, Manon Girard, David Z. I. Cherney, Marcel H. A. Muskiet   +6 more
wiley   +1 more source

Dysregulation of renin-angiotensin-aldosterone axis in septic shock: Emerging roles of angiotensin-(1-5) and alamandine. [PDF]

World J Crit Care Med
Srinivasan A, Dhivya P.
europepmc   +1 more source

The role of peripheral serotonin in SARS‐CoV‐2 infectivity, COVID‐19 treatment and long COVID

Immunology &Cell Biology, Volume 104, Issue 4, Page 368-376, April 2026.
In this article, we discuss how SARS‐CoV‐2 infects the gastrointestinal tract, that enterochromaffin cells, the source of circulating serotonin, uniquely express viral entry receptors. We examine how this infection disrupts gut‐derived serotonin, contributing to gastrointestinal symptoms and disease severity, and link elevated plasma serotonin to COVID‐
Daniel W Thorpe, Lauren A Jones, Alyce M Martin, Rosemary A Coleman, Caitlin Allman, Rochelle A Peterson, Damien J Keating   +6 more
wiley   +1 more source

Genetic Analysis and Clinical Effect of <i>ACE2</i> Gene Variants (rs2285666 and rs4646188) on Coronary Syndrome in Dyslipidaemia Patients. [PDF]

Sultan Qaboos Univ Med J
Abdulfattah SY, Saady S.
europepmc   +1 more source

ACE2 overexpression in the paraventricular nucleus attenuates angiotensin II-induced hypertension [PDF]

, 2011
Srinivas Sriramula, Jeffrey P. Cardinale, Eric Lazartigues, Joseph Francis   +3 more
openalex   +1 more source

Age‐related differences in mRNA vaccine immunogenicity and adjuvancy

Immunology &Cell Biology, Volume 104, Issue 4, Page 400-414, April 2026.
Older people often respond poorly to mRNA vaccines, with reduced T and B cell responses, but they also bear more morbidity and mortality for infectious diseases. This paper maps age‐related changes in mechanisms of adjuvancy that can shape the immunogenicity of mRNA vaccine in a mouse model. Created in BioRender.
Shivali Savita Chinni, Gemma S Trollope, Patrick Leung, Jonathan L McQualter, Chee Wah Tan, Linfa Wang, Leonard Lim, Adam K Wheatley, Jennifer A Juno, Stephen J Kent, Hareth A Al‐Wassiti, Colin W Pouton, Kylie M Quinn   +12 more
wiley   +1 more source

SARS-CoV-2 antibody-dependent enhancement of infection depends on antibody binding to both ACE2 and Fc receptors. [PDF]

JCI Insight
Kuzmina NA, Periasamy S, Kedarinath K, Hernandez K, Atyeo C, Dennison SM, Li K, Bedinger D, Schendel SL, Tomaras GD, Ali H, Alter G, Saphire EO, Bukreyev A.   +13 more
europepmc   +1 more source

ACE2 activity is increased in monocyte-derived macrophages from prehypertensive subjects [PDF]

, 2006
S Keidar, Alexander Strizevsky, Ayelet Raz, Aviva Gamliel-Lazarovich   +3 more
openalex   +1 more source

An infection and pathogenesis mouse model of SARS‐CoV‐2‐related pangolin coronavirus GX_P2V(short_3UTR)

mLife, Volume 5, Issue 2, Page 259-262, April 2026.
Lai Wei, Shuiqing Liu, Shanshan Lu, Shengdong Luo, Xiaoping An, Huahao Fan, Erguang Li, Lihua Song   +7 more
wiley   +1 more source

Mass‐Standardised Differential Antibody Binding to a Spectrum of SARS‐CoV‐2 Variant Spike Proteins: Wuhan, Alpha, Beta, Gamma, Delta, Omicron BA.1, BA.4/5, BA.2.75 and BA.2.12.1 Variants—Antibody Immunity Endotypes

Immunology, Volume 177, Issue 4, Page 798-809, April 2026.
Fully quantitative, mass‐standardised, antibody responses to ten SARS‐CoV‐2 variants show significant variation in immunity profiles or endotypes. The incidence of the complete response to all variants is significantly improved after three vaccinations.
Philip H. James‐Pemberton, Shivali Kohli, Jordan Twynham, Aaron C. Westlake, Alex Antill, Rouslan V. Olkhov, Andrew M. Shaw   +6 more
wiley   +1 more source