A Human β-Defensin-Based Recombinant Protein DF2-HSA Ameliorates Cytokine Storm [PDF]
CellsCytokine storm is a critical driver of acute respiratory distress syndrome and multiple organ failure. Human β-defensin 2 (HBD-2) is the first inducible defensin discovered in human body.
Yibo Du +7 more
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Frontiers in Immunology, 2020 Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure.
Sonu Bhaskar +2 more
exaly +3 more sources
Ebola Virus Binding to Tim-1 on T Lymphocytes Induces a Cytokine Storm
MBio, 2017 Ebola virus (EBOV) disease (EVD) results from an exacerbated immunological response that is highlighted by a burst in the production of inflammatory mediators known as a “cytokine storm.” Previous reports have suggested that nonspecific activation of T ...
Mathieu Iampietro +2 more
exaly +3 more sources
CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease
Nature Communications, 2022 Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab.
Sheila K. Pierson +11 more
doaj +1 more source
The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease
Haematologica, 2022 Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna +4 more
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Absence of “Cytokine Storm” in Hospitalized COVID-19 Patients: A Retrospective Cohort Study
Infectious Disease Reports, 2021 Background: A rapidly growing number of publications cite “cytokine storm” as a contributing factor in coronavirus disease 2019 (COVID-19) pathology. However, a few recent reports led to questioning of “cytokine storm” theory in COVID-19.
Maeghan L. Ciampa +6 more
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Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]
, 2020 On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P. +4 more
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Repurposing Interleukin-6 Inhibitors to Combat COVID-19. [PDF]
, 2020 Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is a pandemic with major implications across the world. One of the most frequent causes of death from SARS-CoV-2 is fatal pneumonia from coronavirus disease 2019 (COVID-19), which is associated
Kato, Shumei, Kurzrock, Razelle
core +1 more source
Can Panax ginseng help control cytokine storm in COVID-19?
Journal of Ginseng Research, 2022 Coronavirus disease 2019 (COVID-19) is currently a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 are directly associated with hyper-activation of innate immune response that excessively produce pro-inflammatory
Jong Hee Choi +5 more
doaj +1 more source
Brain dysfunction in COVID‐19 and CAR‐T therapy: cytokine storm‐associated encephalopathy
Annals of Clinical and Translational Neurology, 2021 Objective Many neurological manifestations are associated with COVID‐19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID‐19 patients.
Umberto Pensato +7 more
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