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IMMUNOPATHOLOGY AND IMMUNOPHARMACOTHERAPY OF CORONAVIRUS DISEASE 2019 (COVID-19): FOCUS ON INTERLEUKIN 6

Научно-практическая ревматология, 2020
The Coronavirus Disease 2019 (COVID-19) pandemic has drawn closer attention than ever before to the problems of the immunopathology of human diseases, many of which have been reflected when studying immune-mediated inflammatory rheumatic diseases (IIRDs).
E. L. Nasonov
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Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells

Cells, 2021
Cytokine storm syndrome is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress.
Bahareh Hafezi, Lily Chan, Jason P. Knapp, Negar Karimi, Kimia Alizadeh, Yeganeh Mehrani, Byram W. Bridle, Khalil Karimi   +7 more
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Dynamics of a cytokine storm. [PDF]

PLoS ONE, 2012
Six volunteers experienced severe inflammatory response during the Phase I clinical trial of a monoclonal antibody that was designed to stimulate a regulatory T cell response.
Hao Hong Yiu, Andrea L Graham, Robert F Stengel   +2 more
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Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm

Life, 2022
COVID-19-infected patients require an intact immune system to suppress viral replication and prevent complications. However, the complications of SARS-CoV-2 infection that led to death were linked to the overproduction of proinflammatory cytokines known ...
Abdullahi Rabiu Abubakar, Rahnuma Ahmad, Adekunle Babajide Rowaiye, Sayeeda Rahman, Katia Iskandar, Siddhartha Dutta, Angus Nnamdi Oli, Sameer Dhingra, Maryam Abba Tor, Ayukafangha Etando, Santosh Kumar, Mohammed Irfan, Marshall Gowere, Kona Chowdhury, Farhana Akter, Dilshad Jahan, Natalie Schellack, Mainul Haque   +17 more
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Into the storm: the imbalance in the yin-yang immune response as the commonality of cytokine storm syndromes

Frontiers in Immunology
There is a continuous cycle of activation and contraction in the immune response against pathogens and other threats to human health in life. This intrinsic yin-yang of the immune response ensures that inflammatory processes can be appropriately ...
Amy Armstrong, Amy Armstrong, Yuting Tang, Neelam Mukherjee, Neelam Mukherjee, Nu Zhang, Gang Huang, Gang Huang, Gang Huang   +8 more
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Immune response and cytokine storm in SARS-CoV-2 infection: Risk factors, ways of control and treatment

European Journal of Inflammation, 2022
In 2020, a deadly pandemic caused by the SARS-COV-2 virus spread worldwide and killed many people. In some viral infections, in addition to the pathogenic role of the virus, impaired immune function leads to inflammation and further damage in internal ...
Hamid Chegni, Hadise Babaii, Zuhair M Hassan, Manoochehr Pourshaban   +3 more
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Cytokines and COVID-19: friends or foes?

Human Vaccines & Immunotherapeutics, 2020
The cytokine storm following sepsis has been proven to be an important mechanism for triggering acute respiratory distress syndrome, which is a fatal uncontrolled systemic inflammation characterized by high concentrations of pro-inflammatory cytokines ...
Mohsen Rokni, Michael R Hamblin, Nima Rezaei   +2 more
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Frontiers and hotspots evolution in cytokine storm: A bibliometric analysis from 2004 to 2022

Heliyon
Background: As a fatal disease, cytokine storm has garnered research attention in recent years. Nonetheless, as the body of related studies expands, a thorough and impartial evaluation of the current status of research on cytokine storms remains absent ...
Junyi Shen, Jiaming Li, Yuqi Lei, Zhengrui Chen, Lingling Wu, Chunyan Lin   +5 more
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Pharmacological validation of a novel exopolysaccharide from Streptomyces sp. 139 to effectively inhibit cytokine storms

Heliyon
With the rapid development of immunotherapy in recent years, cytokine storm has been recognized as a common adverse effect of immunotherapy. The emergence of COVID-19 has renewed global attention to it.
Zhuochen Zhuang, Yu Chen, Zhe Liu, Yu Fu, Fei Wang, Liping Bai   +5 more
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Erratum to: Longitudinal, natural history study reveals the disease burden of idiopathic multicentric Castleman disease

Haematologica, 2020
Mateo Sarmiento Bustamante, Sheila K. Pierson, Yue Ren, Adam Bagg, Joshua D. Brandstadter, Gordan Srkalovic, Natalie Mango, Daisy Alapat, Mary Jo Lechowicz, Hongzhe Li, Frits van Rhee, Megan S. Lim, David C. Fajgenbaum   +12 more
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