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Cytokine Storm Syndrome in SARS-CoV-2 Infections: A Functional Role of Mast Cells. [PDF]

Cells, 2021
Cytokine storm syndrome is a cascade of escalated immune responses disposing the immune system to exhaustion, which might ultimately result in organ failure and fatal respiratory distress.
Hafezi B, Chan L, Knapp JP, Karimi N, Alizadeh K, Mehrani Y, Bridle BW, Karimi K.   +7 more
europepmc   +5 more sources

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue. [PDF]

Emerg Microbes Infect, 2021
SARS-CoV-2 has claimed 2,137,908 lives in more than a year. Some COVID-19 patients experience sudden and rapid deterioration with the onset of fatal cytokine storm syndrome (CSS), which have increased interest in CSS’s mechanisms, diagnosis and therapy ...
Yongzhi X.
europepmc   +4 more sources

Efficacy of Tocilizumab Therapy in Different Subtypes of COVID-19 Cytokine Storm Syndrome. [PDF]

Viruses, 2021
Background: Cytokine storm in COVID-19 is heterogenous. There are at least three subtypes: cytokine release syndrome (CRS), macrophage activation syndrome (MAS), and sepsis. Methods: A retrospective study comprising 276 patients with SARS-CoV-2 pneumonia.
Oliynyk O, Barg W, Slifirczyk A, Oliynyk Y, Gurianov V, Rorat M.   +5 more
europepmc   +4 more sources

Case Report: Cytokine storm syndrome causing retinal inflammatory factor storm. [PDF]

Front Immunol
Cytokine storm syndrome (CSS) represents a severe systemic inflammatory condition precipitated by the hyperactivation of immune cells and the consequent excessive release of cytokines, triggered by various factors.
Liu N, Bai J, Zhai G, Wang S.
europepmc   +2 more sources

Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19. [PDF]

Arch Med Res, 2020
Presently, we need more therapeutic molecules for this COVID-19 outbreak. The severity and mortality of the disease is associated with a high level of release of cytokine in the patients which is known as CRS (cytokine release syndrome) or cytokine storm
Saha A, Sharma AR, Bhattacharya M, Sharma G, Lee SS, Chakraborty C.   +5 more
europepmc   +3 more sources

Brain dysfunction in COVID‐19 and CAR‐T therapy: cytokine storm‐associated encephalopathy [PDF]

Annals of Clinical and Translational Neurology, 2021
Objective Many neurological manifestations are associated with COVID‐19, including a distinct form of encephalopathy related to cytokine storm, the acute systemic inflammatory syndrome present in a subgroup of COVID‐19 patients.
Umberto Pensato, Lorenzo Muccioli, Ilaria Cani, Damir Janigro, Pier Luigi Zinzani, Maria Guarino, Pietro Cortelli, Francesca Bisulli   +7 more
doaj   +3 more sources

Cytokine storm syndrome in coronavirus disease 2019: A narrative review. [PDF]

J Intern Med, 2021
Gao YM, Xu G, Wang B, Liu BC.
europepmc   +2 more sources

Multi-organ pathology in a small porcine model of cytokine storm syndrome characteristics. [PDF]

Front Immunol
Jin J, Fan L, Chen R, Lin X, Zhang S, Zhu M.   +5 more
europepmc   +2 more sources

Neutrophil-macrophage communication via extracellular vesicle transfer promotes itaconate accumulation and ameliorates cytokine storm syndrome. [PDF]

Cell Mol Immunol
Kang H, Liu T, Wang Y, Bai W, Luo Y, Wang J.   +5 more
europepmc   +2 more sources

COVID-19 Pathology on Various Organs and Regenerative Medicine and Stem Cell-Based Interventions

Frontiers in Cell and Developmental Biology, 2021
Severe acute respiratory syndrome-coronavirus 2, a novel betacoronavirus, has caused the global outbreak of a contagious infection named coronavirus disease-2019. Severely ill subjects have shown higher levels of pro-inflammatory cytokines.
Babak Arjmand, Sepideh Alavi-Moghadam, Peyvand Parhizkar Roudsari, Mostafa Rezaei-Tavirani, Fakher Rahim, Kambiz Gilany, Kambiz Gilany, Kambiz Gilany, Fereshteh Mohamadi-Jahani, Hossein Adibi, Bagher Larijani   +10 more
doaj   +1 more source