Results 41 to 50 of about 86,839 (276)
CD28 between tolerance and autoimmunity: The side effects of animal models [version 1; referees: 2 approved] [PDF]
, 2018 Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
A Aruffo +57 more
core +2 more sources
The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections
Frontiers in Immunology, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless infections and caused millions of deaths since its emergence in 2019.
Ren-Jun Hsu +10 more
doaj +1 more source
The role of Th17 cells in SARS-CoV-2 infection: implementation for the therapy of severe COVID-19 cases [PDF]
CellR4, 2021 In this opinion paper, we discuss the implementation of Th17 cells in the pathophysiology of SARS-CoV-2 infection, with regard to cytokine storm, acute respiratory distress syndrome (ARDS), and other COVID-19 complications. Indeed, the imbalance of IL-17
T. Velikova +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory disease caused by the severe acute respiratory syndrome coronavirus 2. A significant proportion of COVID-19 patients develop Acute Respiratory Distress Syndrome (ARDS) resulting from ...
Prakash Nagarkatti +3 more
doaj +1 more source
Oncologic Emergencies: Immune-Based Cancer Therapies and Complications [PDF]
, 2020 Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from ...
Brém, Elizabeth +2 more
core
Frontiers in Cardiovascular Medicine, 2020 The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has led to 47 m infected cases and 1. 2 m (2.6%) deaths.
Georgina M. Ellison-Hughes +5 more
doaj +1 more source
Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]
, 2014 Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter +4 more
core +1 more source
Promising Adjunct Medicines in the Protocol of COVID-19 Clinical Trial [PDF]
Advanced Pharmaceutical Bulletin, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative organism ofCOVID-19. Since this disease is considered new and does not have an approved curativeprotocol, many researchers have tackled the possible options for COVID-19 ...
Mona Mahmoud AbouSamra +1 more
doaj +1 more source
Heart and Mind, 2021 More than 20 million human beings got infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and suffered from coronavirus disease 2019 (COVID-19) disease in the current global pandemic. This disease flow showed a heterogeneous spectrum
Saloni Malik +4 more
doaj +1 more source
Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. [PDF]
, 2018 BACKGROUND: The pathogenesis of macrophage activation syndrome (MAS) is not clearly understood: a large body of evidence supports the involvement of mechanisms similar to those implicated in the setting of primary hemophagocytic lymphohistiocytosis ...
Bracaglia, Claudia +10 more
core +1 more source