Results 51 to 60 of about 1,637,423 (248)

Mechanisms and therapeutic strategies of sepsis-associated cytokine storm [PDF]

Jichu yixue yu linchuang
Sepsis is one of the most common critical conditions in clinical practice, with a persistently high mortality rate. As the core pathological mechanism of sepsis, cytokine storm, the continuous activation of the immune system and the disordered release of
WANG Tingting, QIN Haidong
doaj   +1 more source

Role of DOCK8 in cytokine storm syndromes

Journal of Allergy and Clinical Immunology
Cytokine storm syndromes (CSSs), including hemophagocytic lymphohistiocytosis (HLH), are increasingly recognized as hyperinflammatory states leading to multiorgan failure and death. Familial HLH in infancy results from homozygous genetic defects in perforin-mediated cytolysis by CD8 T lymphocytes and natural killer (NK) cells.
Mingce Zhang, Remy R. Cron, Niansheng Chu, Junior Nguyen, Scott M. Gordon, Esraa M. Eloseily, T. Prescott Atkinson, Peter Weiser, Mark R. Walter, Portia A. Kreiger, Scott W. Canna, Edward M. Behrens, Randy Q. Cron   +12 more
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects

Stem Cell Research & Therapy, 2021
Novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2. The virus causes an exaggerated immune response, resulting in a cytokine storm and acute respiratory distress syndrome, the leading cause of COVID-19 ...
Mai Abdelgawad, Nourhan Saied Bakry, Ahmed A. Farghali, Ahmed Abdel-Latif, Ahmed Lotfy   +4 more
doaj   +1 more source

Rapid Radiological Worsening and Cytokine Storm Syndrome in COVID-19 Pneumonia. [PDF]

Eur J Case Rep Intern Med, 2020
Background: In June 2020, a large randomised controlled clinical trial in the UK found that dexamethasone was effective in reducing the number of deaths in patients with severe coronavirus disease 2019 (COVID-19).
Ruch Y, Kaeuffer C, Guffroy A, Lefebvre N, Hansmann Y, Danion F.   +5 more
europepmc   +2 more sources

ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway

iScience, 2021
Summary: Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that patients with severe COVID-19 may suffer from cytokine storm syndrome; however, there are few studies ...
Xiaoyuan Lin, Beibei Fu, Songna Yin, Zhifeng Li, Huawen Liu, Haiwei Zhang, Na Xing, Yu Wang, Weiwei Xue, Yan Xiong, Shanfu Zhang, Qingting Zhao, Shiyao Xu, Jing Zhang, Peihui Wang, Weiqi Nian, Xingsheng Wang, Haibo Wu   +17 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

COVID-19: consider cytokine storm syndromes and immunosuppression [PDF]

The Lancet, 2020
Indisponível.
Mehta, Puja, McAuley, Daniel F., Brown, Michael, Sanchez, Emilie, Tattersall, Rachel S., Manson, Jessica J.   +5 more
openaire   +3 more sources

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source