Results 51 to 60 of about 86,839 (276)
Treatment Options during Cytokine Storm
Dr. Sulaiman Al Habib Medical Journal, 2021 Cytokine storm is the major cause of death in patients with acute respiratory distress caused by COVID-19. Because cytokine storm is a life-threatening condition, it is important to treat patients with the most appropriate drugs depending on their ...
Abdullah Alkattan +2 more
doaj +1 more source
One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]
, 2015 Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA +8 more
core +1 more source
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 [PDF]
, 2018 CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic ...
Alarcon, Balbino +13 more
core +5 more sources
Mechanisms and therapeutic strategies of sepsis-associated cytokine storm [PDF]
Jichu yixue yu linchuangSepsis is one of the most common critical conditions in clinical practice, with a persistently high mortality rate. As the core pathological mechanism of sepsis, cytokine storm, the continuous activation of the immune system and the disordered release of
WANG Tingting, QIN Haidong
doaj +1 more source
Role of DOCK8 in cytokine storm syndromes
Journal of Allergy and Clinical ImmunologyCytokine storm syndromes (CSSs), including hemophagocytic lymphohistiocytosis (HLH), are increasingly recognized as hyperinflammatory states leading to multiorgan failure and death. Familial HLH in infancy results from homozygous genetic defects in perforin-mediated cytolysis by CD8 T lymphocytes and natural killer (NK) cells.
Mingce Zhang +12 more
openaire +2 more sources
Forbes Tıp Dergisi, 2020 Although the etiopathogenesis of infections has been largely illuminated by technical and scientific developments in the past century; many issues are still not clear today. The word 'there is no disease, there is a patient' is stil valid today.
Mustafa Kurtuluş, Ibrahim Pirim
doaj +1 more source
TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease [PDF]
, 2018 Hemodynamic collapse and myocardial dysfunction are among the major causes ofdeath in severe sepsis. The purpose of this study was to assess the role played by TLR4and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after ...
Branda, Hugo Justino +10 more
core +2 more sources
COVID-19: consider cytokine storm syndromes and immunosuppression [PDF]
The Lancet, 2020 Indisponível.
Mehta, Puja +5 more
openaire +3 more sources
Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
A Rare Case of Hemophagocytic Lymphohistiocytosis of Unknown Etiology [PDF]
, 2017 Hemophagocytic lymphohistiocytosis (HLH) is an uncommon cytokine storm syndrome marked which can cause high mortality. In adults, acquired HLH usually has an underlying infectious, autoimmune or malignant process that triggers the syndrome.
Damsker, Jason A. +3 more
core +1 more source