Results 221 to 230 of about 132,338 (329)

Angiotensin‑converting enzyme 2 as an immune and prognostic biomarker in colorectal cancer. [PDF]

Sci Rep
Liu G, Yu X, Jiang W, He X, Nie H, Ou C.
europepmc   +1 more source

Liquid–Liquid Phase Separation in Viral Infection and Immunology

MedComm, Volume 7, Issue 4, April 2026.
LLPS organizes viral replication and antiviral immunity. Viruses hijack LLPS to form replication factories and evade immune sensors, while hosts assemble LLPS‐driven signaling hubs (e.g., MAVS, RIG‐I, and SGs) to amplify interferon responses. Targeting these condensate interfaces offers novel therapeutic strategies against infectious diseases ...
Jiuzhi Xu, Lan Bai, Bin Wang, Hai Song, Long Zhang, Fangfang Zhou   +5 more
wiley   +1 more source

The Application of Metal–Organic Frameworks as Drug Delivery Systems: From the Perspective of Molecular Dynamics Simulations

MedComm, Volume 7, Issue 4, April 2026.
This review article provides a comprehensive exploration of the synergistic integration of molecular dynamics (MD) simulations and metal–organic frameworks (MOFs) to advance the design and optimization of nanoscale drug delivery systems (DDSs). We believe this work will be of significant interest to researchers in nanomedicine, computational biology ...
Jiahao Xu, Hanzi Zheng, Yue Gao, Yuanqiu Lai, Mengya Peng, Yike Hu, Tianmeng Yuan, Xiang Liu, Shihan Zhou, Wei Duan, Jia‐Wei Shen, Yongke Zheng   +11 more
wiley   +1 more source

Mas‐Related G Protein‐Coupled Receptor Member D Sustains Hypertension

MedComm, Volume 7, Issue 4, April 2026.
Targeting MrgD attenuated hypertension and alleviated hypertension‐associated vascular remodeling via repressing Cav1.2‐CaMKIIγ axis. Risperidone, a small‐molecule inhibitor of MrgD, could alleviate hypertension and artery remodeling induced by Ang II infusion.
Kun Zhao, Dongxu Hua, Yukang Mao, Xiaoguang Wu, Min Gao, Shidong Song, Lei Chen, Xiangxiang Zheng, Peng Li   +8 more
wiley   +1 more source

SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells. [PDF]

PLoS Pathog
Cheung PH, Chan P, Yang H, Ambrus K, Honne S, Kim B, Perlman S, Wu L.   +7 more
europepmc   +1 more source

Computational prediction of binding affinity and structural impact of three Pakistani SARS-CoV-2 spike RBD variants on human ACE2 interaction. [PDF]

PLoS One
Usama M, Azeem M, Mustafa G.
europepmc   +1 more source

In vivo negative regulation of SARS-CoV-2 receptor, ACE2, by interferons and its genetic control

, 2021
M. Azim Ansari, Emanuele Marchi, Narayan Ramamurthy, Dominik Aschenbrenner, Sophie Morgan, Carl-Philipp Hackstein, ISARIC-4C Investigators, Shang‐Kuan Lin, Rory Bowden, Eshita Sharma, Vincent Pedergnana, Suresh Venkateswaran, Subra Kugathasan, Angela Mo, Greg Gibson, Graham Cooke, John McLauchlan, J. Kenneth Baillie, Sarah A. Teichmann, Alexander J. Mentzer, Julian C. Knight, John A. Todd, Timothy Hinks, Eleanor Barnes, Holm H. Uhlig, Paul Klenerman   +25 more
openalex   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, Volume 7, Issue 2, April 2026.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

Hierarchical Testing of a Hybrid Machine Learning‐Physics Global Atmosphere Model

AGU Advances, Volume 7, Issue 2, April 2026.
Abstract Machine learning (ML)‐based models have demonstrated high skill and computational efficiency, often outperforming conventional physics‐based models in weather and subseasonal predictions. While prior studies have assessed their fidelity in capturing synoptic‐scale atmospheric dynamics, their performance across timescales and under out‐of ...
Ziming Chen, L. Ruby Leung, Wenyu Zhou, Jian Lu, Sandro W. Lubis, Ye Liu, Chuan‐Chieh Chang, Bryce E. Harrop, Ya Wang, Mingshi Yang, Gan Zhang, Yun Qian   +11 more
wiley   +1 more source

Machine learning-guided rational engineering of ACE2-derived peptides for broad-spectrum neutralization of SARS-CoV-2 variants. [PDF]

Saudi Pharm J
Alamri MA, Alawam AS.
europepmc   +1 more source