Results 21 to 30 of about 65,941 (263)

Spontaneous Hinge-Bending Motions of Angiotensin I Converting Enzyme: Role in Activation and Inhibition

Molecules, 2020
The inhibition of human angiotensin I converting enzyme (ACE) has been regarded as a promising approach for the treatment of hypertension. Despite research attempts over many years, our understanding the mechanisms of activation and inhibition of ACE is ...
Thi Tuong Vy, Seong-Yeong Heo, Won-Kyo Jung, Myunggi Yi   +3 more
doaj   +1 more source

Identification of a novel hypotensive peptide from porcine plasma hydrolysate by in vitro digestion and rat model

Food Chemistry: Molecular Sciences, 2022
We separated a novel functional peptide IFPPKPKDTL from porcine plasma hydrolysate by chromatography, HPLC, and identified by Q Exactive LC-MS/MS. Results showed that IFPPKPKDTL had a significant ability of ACE inhibition (76.6%) likely due to the ...
Junqi Zhan, Gaoshang Li, Yali Dang, Daodong Pan   +3 more
doaj   +1 more source

Tribiotication strategy for the functionalization of bovine colostrum through the biochemical activities of artisanal and selected starter cultures

CyTA - Journal of Food, 2020
The main aim of this study was to transform bovine colostrum into a tribiotic product through a metabolic conversion with a microbial consortium based on artisanal and starter microorganisms.
Mihaela Cotârleţ, Aida Mihaela Vasile, Alexandra Gaspar-Pintiliescu, Anca Oancea, Gabriela Elena Bahrim   +4 more
doaj   +1 more source

Characterization of ACE Inhibitory Peptides Prepared from Pyropia pseudolinearis Protein

Marine Drugs, 2021
More than 7000 red algae species have been classified. Although most of them are underused, they are a protein-rich marine resource. The hydrolysates of red algal proteins are good candidates for the inhibition of the angiotensin-I-converting enzyme (ACE)
Yuya Kumagai, Keigo Toji, Satoshi Katsukura, Rie Morikawa, Toshiki Uji, Hajime Yasui, Takeshi Shimizu, Hideki Kishimura   +7 more
doaj   +1 more source

Three Novel ACE Inhibitory Peptides Isolated From Ginkgo biloba Seeds: Purification, Inhibitory Kinetic and Mechanism

Frontiers in Pharmacology, 2019
Alcalase, dispase, trypsin, and flavourzyme were used to hydrolyze the extracted Ginkgo biloba seeds protein isolate (GPI). The Ginkgo protein hydrolyzates (GPHs) with the maximum degree of hydrolysis (DH) and ACE inhibitory activity were selected, and ...
Fei-Fei Ma, Hao Wang, Hao Wang, Chao-Kun Wei, Kiran Thakur, Zhao-Jun Wei, Zhao-Jun Wei, Li Jiang   +7 more
doaj   +1 more source

Cordyceps militaris Inhibited Angiotensin-Converting Enzyme through Molecular Interaction between Cordycepin and ACE C-Domain

Life, 2022
One of the most important therapeutic modalities for the management of hypertension is the inhibition of the angiotensin-converting enzyme (ACE). Cordyceps militaris has received substantial attention because to its therapeutic potential and biological ...
Mónica A. Valdez-Solana, Iván A. Corral-Guerrero, Alfredo Téllez-Valencia, Claudia Avitia-Domínguez, Jorge A. Meza-Velázquez, Atahualpa Guzmán de Casa, Erick Sierra-Campos   +6 more
doaj   +1 more source

Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk

Journal of Advanced Research, 2017
Angiotensin-converting enzyme (ACE) plays a central role in blood pressure regulation by producing the vasoconstrictor angiotensin II. The inhibition of ACE with natural inhibitors, as alternatives to avoid the side effect of synthetic drugs, is a major ...
Hisham R. Ibrahim, Ahmed S. Ahmed, Takeshi Miyata   +2 more
doaj   +1 more source

Effect of tofacitinib therapy on angiotensin converting enzyme activity in rheumatoid arthritis

Frontiers in Medicine, 2023
IntroductionThe Renin-Angiotensin-Aldosterone system (RAAS) has been implicated in the regulation of the cardiovascular system and linked to rheumatoid arthritis (RA).
Dorottya Kacsándi, Miklós Fagyas, Ágnes Horváth, Edit Végh, Anita Pusztai, Monika Czókolyová, Boglárka Soós, Attila Ádám Szabó, Attila Ádám Szabó, Attila Hamar, Zsófia Pethő, Nóra Bodnár, György Kerekes, Katalin Hodosi, Szilvia Szamosi, Gabriella Szűcs, Zoltán Papp, Zoltán Szekanecz   +17 more
doaj   +1 more source

南瓜籽ACE抑制肽的Plastein反应修饰及分离鉴定Plastein reaction modification of pumpkin seed ACE inhibitory peptide and its isolation and identification

Zhongguo youzhi, 2023
为进一步提升南瓜籽多肽的ACE抑制活性，利用Plastein反应对南瓜籽ACE抑制肽进行修饰，探究底物质量分数、反应温度、反应时间以及3种外源氨基酸添加量对ACE抑制率的影响。采用超滤和Sephadex G-25柱层析等分离修饰产物，并利用LC-MS/MS鉴定肽序列。结果表明：Plastein反应修饰的最佳条件为底物质量分数45%，反应温度20 ℃，反应时间3 h；分别添加亮氨酸、苯丙氨酸或甘氨酸均能显著提升修饰产物的ACE抑制率，其中添加0.5 mmol/g亮氨酸时，修饰产物的ACE抑制率最高 ...
胡田媛1,杨晨1，陈哲2,3，郑竟成1,3，何东平1,3，杨永2,3，雷芬芬1,3 HU Tianyuan1, YANG Chen1, CHEN Zhe2,3, ZHENG Jingcheng1,3, HE Dongping1,3, YANG Yong2,3, LEI Fenfen1,3
doaj   +1 more source

Mobola plum seed methanolic extracts exhibit mixed type inhibition of angiotensin Ⅰ-converting enzyme in vitro

Asian Pacific Journal of Tropical Biomedicine, 2017
Objective: To explore the possible inhibitory potentials and mechanism by Mobola plum (Parinari curatellifolia) seeds crude methanol (CE) and flavonoid-rich (FE) extracts on angiotensin-1-converting enzyme (ACE Ⅰ).
Olamide Olajusi Crown, Olanrewaju Sam Olayeriju, Ayodele Oluwaseyi Kolawole, Afolabi Clement Akinmoladun, Mary Tolulope Olaleye, Afolabi Akintunde Akindahunsi   +5 more
doaj   +1 more source