Results 91 to 100 of about 157,438 (357)

Drivers for change in primary care of diabetes following a protected learning time educational event: interview study of practitioners [PDF]

, 2008
Background: A number of protected learning time schemes have been set up in primary care across the United Kingdom but there has been little published evidence of their impact on processes of care.
Middlemass, Jo B., Siriwardena, A. Niroshan, Ward, Kate, Wilkinson, Carol   +3 more
core   +2 more sources

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

ACE inhibitors in patients with acute myocardial infarction

Кардиоваскулярная терапия и профилактика, 2005
The article is devoted to modern perspectives of ACE inhibitor therapy in patients with acute myocardial infarction (AMI). ACE inhibitor efficacy is analyzed, according to the results of large randomized studies.
S. N. Tereshchenko, N. A. Dzhaiani
doaj  

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

FIXED COMBINATION OF THE CALCIUM CHANNEL BLOCKER LERCANIDIPINE AND ANGIOTENSIN CONVERTING ENZYME INHIBITOR ENALAPRIL: POSSIBILITY OF USAGE

Рациональная фармакотерапия в кардиологии, 2015
Data on the updated approach to the choice of two-component antihypertensive combinations for different clinical situations are presented. Advantages and indications for combination of an angiotensin converting enzyme (ACE) inhibitor and dihydropyridine ...
O. D. Ostroumova, I. I. Kopchenov
doaj   +3 more sources

NEW APPROACHES OF THE HYPERTENSION TREATMENT: FROM CHOOSING THE BEST DRUG TO CHOOSE THE OPTIMUM DRUGS COMBINATION

Рациональная фармакотерапия в кардиологии, 2016
The possible indications for the choice of two component antihypertensives combinations are presented. The advantages of ACE inhibitor+calcium channel blocker combination are shown in terms of antihypertensive efficacy, organoprotective properties, and ...
O. D. Ostroumova, E. A. Smolyarchuk, I. V. Khvorostyanaya   +2 more
doaj   +1 more source

Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter [PDF]

, 2009
BACKGROUND. Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation. OBJECTIVE. We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) and in diastolic blood ...
Andrea Baccarelli, Audrey Poon, Augusto A. Litonjua, Benjamini Y, David Sparrow, Elissa Wilker, Ferris BG, Helen Suh, Joel Schwartz, Murray A. Mittleman, Pantel Vokonas, Poon AH, Poon AH, Robert O. Wright   +13 more
core   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

ACE-ing Angioedema: A National Inpatient Sample Cohort Comparing All-cause Angioedema and ACE-I Induced Angioedema

Journal of Advanced Lung Health
Introduction: Angioedema, particularly when induced by angiotensin-converting enzyme (ACE) inhibitors, represents a significant clinical concern due to its potential severity, including life-threatening airway obstruction.
Sudeep Acharya, Yisroel Grabie, Sakura Thapa, Zeina Morcos, Stefan Nicholas Hamaway, Chapman Wei, Gabriel Chavez Reyna, Dany Elsayegh, Halim El-Hage, Thomas Michael Kilkenny, Rabih Maroun, Matt Flamenbaum, Michel Chalhoub   +12 more
doaj   +1 more source