Results 81 to 90 of about 89,590 (297)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Structures of ACE inhibitor Enalapril, MR antagonists Spironolactone and Eplerenone, CYP11B2 inhibitor Fadrozole and aromatase inhibitor Exemestane.

, 2012
Structures of ACE inhibitor Enalapril, MR antagonists Spironolactone and Eplerenone, CYP11B2 inhibitor Fadrozole and aromatase inhibitor Exemestane.
Qingzhong Hu (124547), Rolf W. Hartmann (124550), Lina Yin (124546)   +2 more
core   +1 more source

FIXED COMBINATION OF THE CALCIUM CHANNEL BLOCKER LERCANIDIPINE AND ANGIOTENSIN CONVERTING ENZYME INHIBITOR ENALAPRIL: POSSIBILITY OF USAGE

Рациональная фармакотерапия в кардиологии, 2015
Data on the updated approach to the choice of two-component antihypertensive combinations for different clinical situations are presented. Advantages and indications for combination of an angiotensin converting enzyme (ACE) inhibitor and dihydropyridine ...
O. D. Ostroumova, I. I. Kopchenov
doaj   +3 more sources

ACE-ing Angioedema: A National Inpatient Sample Cohort Comparing All-cause Angioedema and ACE-I Induced Angioedema

Journal of Advanced Lung Health
Introduction: Angioedema, particularly when induced by angiotensin-converting enzyme (ACE) inhibitors, represents a significant clinical concern due to its potential severity, including life-threatening airway obstruction.
Sudeep Acharya, Yisroel Grabie, Sakura Thapa, Zeina Morcos, Stefan Nicholas Hamaway, Chapman Wei, Gabriel Chavez Reyna, Dany Elsayegh, Halim El-Hage, Thomas Michael Kilkenny, Rabih Maroun, Matt Flamenbaum, Michel Chalhoub   +12 more
doaj   +1 more source

NEW APPROACHES OF THE HYPERTENSION TREATMENT: FROM CHOOSING THE BEST DRUG TO CHOOSE THE OPTIMUM DRUGS COMBINATION

Рациональная фармакотерапия в кардиологии, 2016
The possible indications for the choice of two component antihypertensives combinations are presented. The advantages of ACE inhibitor+calcium channel blocker combination are shown in terms of antihypertensive efficacy, organoprotective properties, and ...
O. D. Ostroumova, E. A. Smolyarchuk, I. V. Khvorostyanaya   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

In Silico and In Vitro Screening and Mechanisms of Angiotensin I-Converting Enzyme Inhibitory Peptides from Protein Hydrolysates of Royal Jelly

Foods
This work focused on the identification of angiotensin I-converting enzyme (ACE) inhibitory peptides from royal jelly (RJ) proteins and elucidated their inhibition patterns and mechanisms.
Ying Zhang, Shipeng Guo, Haoxiang Miao, Yafei Gu, Jian Zhang   +4 more
doaj   +1 more source

Hidrolisis Protein Tanduk Muda Rusa Sambar (Rusa unicolor) serta Potensinya sebagai Penurun Resiko Hipertensi

Journal of Tropical Pharmacy and Chemistry, 2016
Penelitian  ini  bertujuan  untuk  mengetahui  tingkat  hidrolisis  tanduk muda rusa Sambar (Rusa unicolor) dengan  enzim  pencernaanm  yaitu  enzim  pepsin  dan tripsin,  serta  mengetahui  adanya  aktivitas  Angiotensin  I-Converting Enzyme Inhibitor ...
Arif Ismanto
doaj   +1 more source