Results 91 to 100 of about 89,590 (297)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Angiotensin converting enzyme and vascular endothelial growth factor responses to exercise training in claudicants: the role of ace inhibition

, 2009
Exercise training is well recognised as an effective treatment for intermittent claudication. The mechanism underlying exercise induced improvements is multi-factorial but remains poorly understood.
Ng, P.
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes

, 1997
OBJECTIVE - To evaluate the association between the use of ACE inhibitors and hospital admission for severe hypoglycemia and to explore the effects of potential confounding variables on this relationship.
Boyle, Douglas I R, McMahon, Alex, Evans, Josie, Newton, Ray W., Jung, Roland T., MacDonald, Thomas M, Morris, Andrew D, Morris, Andrew D., Mcmahon, Alexander D., Macdonald, Thomas M., Evans, Josie M.M., Pearce, Hilary, Jung, Roland T, Boyle, Douglas I.R., Newton, Ray W   +14 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Endogenous inhibitor masks ACE activity in human sera.

, 2014
Effects of dilution on the ACE activity were tested on purified renal ACE (Purified ACE) and human serum (A). Plots were fitted by means of linear regressions in case of purified ACE while nonlinear regression was used in case of serum ACE (indicated by ...
Zoltán Papp (5656855), Miklós Fagyas (545422), Andrea Daragó (545425), Katalin Úri (545423), Emese Bányai (545426), Attila Tóth (2847734), Ivetta M. Siket (545424), Judit Boczán (481521), István Édes (481522)   +8 more
core   +1 more source

EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI ACE INHIBITOR LISINOPRIL TERHADAP KEJADIAN BATUK KERING PADA PASIEN HIPERTENSI DI KOMUNITAS GEREJA DI KABUPATEN MALANG

, 2021
Latar belakang: Lisinopril adalah obat antihipertensi dari golongan obat angiotensin converting enzyme inhibitor (ACEi) yang dapat memiliki efek samping batuk kering.
Sitepu, Rehmadanta, Sefiana, Eva, Susanto, F.X. Haryanto   +2 more
core   +1 more source

What is the impact of the ACE gene insertion/deletion (I/D) polymorphism on the clinical effectiveness and adverse events of ACE inhibitors? – Protocol of a systematic review

BMC Medical Genetics, 2004
Background The Angiotensin Converting Enzyme (ACE) insertion/deletion (I/D) polymorphism has received much attention in pharmacogenetic research because observed variations in response to ACE inhibitors might be associated with this polymorphism ...
Steurer J, Puhan MA, Scharplatz M, Bachmann LM   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Quinapril: A New Second-Generation Ace Inhibitor

, 1991
Quinapril is a new non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor. The drug undergoes hepatic hydrolysis into its major active diacid metabolite, quinaprilat, and two minor inactive metabolites. On a weight basis quinaprilat is three times
Anne B. Cetnarowski-Cropp
core   +1 more source