Results 51 to 60 of about 81,765 (240)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Comparative estimation of the effects of antihypertensive medications on schizophrenia occurrence: a multinational observational cohort study

BMC Psychiatry
Background The association between antihypertensive medication and schizophrenia has received increasing attention; however, evidence of the impact of antihypertensive medication on subsequent schizophrenia based on large-scale observational studies is ...
Dong Yun Lee, Chungsoo Kim, Jiwoo Kim, Jeongwon Yun, Yujin Lee, Celine Sze Ling Chui, Sang Joon Son, Rae Woong Park, Seng Chan You   +8 more
doaj   +1 more source

A rare presentation of angioedema with isolated retropharyngeal and supraglottic involvement

Journal of Community Hospital Internal Medicine Perspectives, 2019
Angiotensin converting-enzyme (ACE) inhibitors are commonly prescribed drugs with multiple indications including congestive heart failure, hypertension, and diabetic nephropathy.
H. Patel, S. Kant, R. Chow
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

EFFECTS OF BETAHISTINE DIHYDROCHLORIDE AS ADJUVANT TO ENALAPRIL THERAPY OF PATIENTS WITH CHRONIC HEART FAILURE CLASS II-II (NYHA) SUFFERING FROM GIDDINESS

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study adjuvant effect of betahistine dihydrochloride to ACE inhibitors in patients with chronic heart failure (CHF) class II-III suffering from giddiness.Material and methods.
S. Y. Martsevich, J. V. Lukina, V. V. Yakusevich, D. A. Anichkov, A. D. Deev, O. V. Lerman, S. N. Tolpygina, N. A. Dmitrieva, A. A. Serazhim, M. A. Maksimova, V. P. Voronina, E. V. Shilova, G. F. Andreeva, A. V. Zaharova, I. V. Novikov, А. А. Platonova, Т. А. Kazakovtseva, T. V. Babkova, L. P. Volhonskaya   +18 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

ACE Inhibitor-Induced Angioedema of the Intestine: Case Report, Incidence, Pathophysiology, Diagnosis and Management

Canadian Journal of Gastroenterology, 2001
A case report of fosinopril-induced angioedema of the intestine with a chronic course accompanied by multiple acute exacerbations is described. Angiotensin-converting enzyme (ACE) inhibitor-induced angioedema of the intestine (AIAI) occurs in a minority ...
Gavin Oudit, Nigel Girgrah, Johane Allard   +2 more
doaj   +1 more source

Effect of an angiotensin-converting-enzyme inhibitor on the plasma concentration of cytokines and vasoactive molecules in patients with coronary heart disease and hypertension

Терапевтический архив, 2017
Aim. To investigate the plasma concentrations of cytokines and vasoactive molecules in patients with coronary heart disease (CHD) in the presence of hypertension in relation to the angiotensin-converting-enzyme (ACE) inhibitor level reflecting the degree
A A Khadartsev, A V Logatkina, I V Terekhov, S S Bondar, N V Bondar   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Spirapril – a modern ACE inhibitor

Кардиоваскулярная терапия и профилактика, 2005
An ACE inhibitor, spirapril, is widely used in modern cardiology practice. Its pharmacokinetics is characterized by prolonged elimination half-life, >24 hours. There is no need for dose titration, even in patients with chronic renal failure.
V. M. Gorbunov
doaj