Results 101 to 110 of about 16,784 (281)
HeliyonIn this research, we unveil the medical potential of pearls by identifying a novel bioactive peptide within them for the first time. The peptide, termed KKCHFWPFPW, emerges as a pioneering angiotensin I-converting enzyme (ACE) inhibitor, originating from
Chaoyi Wu +9 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Zhongguo youzhi为改善芝麻ACE抑制肽的味道，分别采用活性炭与树脂对芝麻ACE抑制肽进行脱苦，以脱苦率、多肽损失率为评价指标，采用单因素实验和正交实验对两种脱苦工艺条件进行优化，并比较两种脱苦方法对芝麻ACE抑制肽味觉特性、活性及氨基酸组成的影响，以确定最适宜的脱苦方法。结果表明：两种方法均能使芝麻ACE抑制肽液苦味降至无法察觉，活性炭脱苦最佳工艺条件为活性炭2号添加量6%、芝麻ACE抑制肽液质量浓度10 g/100 mL、吸附温度55 ℃、吸附时间15 min，在此条件下脱苦率与多肽损失率分别为（96.46±0.57）
芦鑫1,2，游静1,2，金璐1,2，宋国辉1,2，孙强1,2，黄纪念1,2,3LU Xin1,2, YOU Jing1,2, JIN Lu1,2, SONG Guohui1,2, SUN Qiang1,2, HUANG Jinian1,2,3
doaj +1 more source
Study on the preparation of ACE inhibitory peptides by probiotic fermentation of quinoa
Shipin yu jixie, 2022 Objective: The potential ability of probiotics to prepare angiotensin-converting enzyme （ACE） inhibitory fermentation broth from quinoa and the effects of fermentation process on it were investigated. Methods: In this study, 18 strains of lactic acid bacteria and 12 strains of yeast were screened for their ability to prepare ACE inhibitory fermentation
LI Shuai, YUAN Ya-hong, YUE Tian-li
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Improving Activity of ACE Inhibitory Peptide by Sequence‐Based Rational Design: Properties, Function on Endothelial Cells, and Potential Antihypertensive Mechanism [PDF]
The comprehension of the relationship between structure and function and mechanisms of intermolecular interactions within amino acid sequences is essential for developing potent angiotensin‐converting enzyme (ACE) inhibitory peptides based on food ...
Dongxing Yu +7 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Preparation and Antihypertensive Effect of Microcapsules Containing Medicinal and Culinary Plant Materials and Angiotensin Converting Enzyme Inhibitory Peptide [PDF]
Shipin KexueIn this study, the antihypertensive effect of microcapsules containing a mixture of goji berry, hawthorn and cassia seed at a mass ratio of 4:1:1 and angiotensin converting enzyme (ACE) inhibitory peptide in spontaneously hypertensive rats (SHR) was ...
XIA Yu, LI Xiaodong, LIU Lu, ZHOU Wenli, JIA Zhibin, JIAO Yang, XIE Qinggang
doaj +1 more source
Analysis of whey protein hydrolysates: peptide profile and ACE inhibitory activity [PDF]
, 2012 The aim of this study was to prepare enzymatic hydrolysates from whey protein concentrate with a nutritionally adequate peptide profile and the ability to inhibit angiotensin-converting enzyme (ACE) activity.
Mariana Wanessa Santana de Souza +11 more
core +2 more sources
Food Science of Animal ProductsTo shorten the complex and time-consuming process of the identification method of the traditional food angiotensin-I-converting enzyme (ACE-I) inhibitory peptides, we propose AHTPeptideFusion based on a segmented fusion with the protein language model ...
Fei Pan +12 more
doaj +1 more source