Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy
Transplant Infectious Disease, Volume 27, Issue 3, May/June 2025.ABSTRACT Vaccine adjuvants are essential for enhancing immune responses to vaccines, particularly in immunocompromised populations who typically demonstrate suboptimal responses to standard vaccination. This narrative review evaluates the safety and efficacy of approved and candidate adjuvants in immunocompromised hosts, with emphasis on solid organ ...
Haya Hayek +8 more
wiley +1 more source
Less reactogenic whole-cell pertussis vaccine confers protection from Bordetella pertussis infection
mSpherePertussis resurged over the last decade in most countries that replaced the traditional whole-cell pertussis vaccines (wP) by the less reactogenic acellular pertussis vaccines (aP).
Karolína Škopová +6 more
doaj +1 more source
BMC Infectious Diseases, 2017 Background Tetanus-reduced dose diphtheria-acellular pertussis (Tdap) vaccination during adolescence was introduced in response to the resurgence of pertussis in various countries.
Hyo Jin Kwon +7 more
doaj +1 more source
New Pertussis Vaccination Strategies beyond Infancy: Recommendations by the Global Pertussis Initiative [PDF]
, 2017 Background. The Global Pertussis Initiative, an expert scientific forum, was established to address the ongoing problems associated with pertussis disease worldwide. Methods.
Campins-Marti, Magda +10 more
core
Oral Polio Vaccination and Hospital Admissions With Non-Polio Infections in Denmark:Nationwide Retrospective Cohort Study [PDF]
, 2015 Background. Live vaccines may have nonspecific beneficial effects on morbidity and mortality. This study examines whether children who had the live-attenuated oral polio vaccine (OPV) as the most recent vaccine had a different rate of admissions for ...
Aaby, Peter +5 more
core +2 more sources
BackgroundIn 2012, over 48,000 pertussis cases were reported in the United States. Many cases occurred in vaccinated persons, showing that pertussis vaccination does not prevent all pertussis cases.
core +6 more sources
PLoS ONE, 2020 Bordetella pertussis vaccine escape mutants that lack expression of the pertussis antigen pertactin (Prn) have emerged in vaccinated populations in the last 10-20 years.
Anne Zeddeman +15 more
doaj +1 more source
Pertussis Immunization for Adolescents: What Are We Waiting for?
Canadian Journal of Infectious Diseases, 2001 Immunization against pertussis (whooping cough) has been part of the routine childhood immunization program for over 50 years. Until 1997, a whole cell pertussis vaccine was used, most often combined with diphtheria and tetanus toxoids; in some ...
SA Halperin
doaj +1 more source
Immunogenicity of a low-dose diphtheria, tetanus and acellular pertussis combination vaccine with either inactivated or oral polio vaccine compared to standard-dose diphtheria, tetanus, acellular pertussis when used as a pre-school booster in UK children : a 5-year follow-up of a randomised controlled study [PDF]
, 2015 This serological follow up study assessed the kinetics of antibody response in children who previously participated in a single centre, open-label, randomised controlled trial of low-dose compared to standard-dose diphtheria booster preschool ...
Baudin, M. +8 more
core +1 more source
Validation of the Vaccination Confidence Scale: A Brief Measure to Identify Parents at Risk for Refusing Adolescent Vaccines [PDF]
, 2016 Objective To validate a brief measure of vaccination confidence using a large, nationally representative sample of parents. Methods We analyzed weighted data from 9018 parents who completed the 2010 National Immunization Survey–Teen, an annual ...
Brewer, Joseph M. +5 more
core +3 more sources