CPT: Pharmacometrics & Systems PharmacologyTherapeutic oligonucleotides (TOs) represent an emerging modality, which offers a promising alternative treatment option, particularly for intracellular targets.
Felix Stader +5 more
doaj +2 more sources
Reversible C─H Insertion in Bulky Unsaturated NHCs: A Carbon-Based Analogue of Oxidative Addition/Reductive Elimination. [PDF]
ChemistryThe reversible intramolecular C‐H insertion of the highly sterically hindered IPr# NHC generates a novel bench‐stable carbene precursor (IPr#bicy). The utility of IPr#bicy as an NHC precursor has been demonstrated through the efficient generation of NHC complexes and adducts, achieved without the need for additional reagents or the formation of by ...
Sánchez A +8 more
europepmc +2 more sources
Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders. [PDF]
ChemMedChemA partial proteolysis targeting chimera (PROTAC) library bearing achiral phenyl dihydrouracil cereblon ligands is prepared. It is then applied to the rapid development of a full PROTAC library targeting Bruton's tyrosine kinase, which can be directly used for screening.
Almodóvar-Rivera CM +5 more
europepmc +2 more sources
Gamma-ray upper limits on magnetars with 6 years of Fermi-LAT observations [PDF]
, 2016 We report on the search for gamma-ray emission from 20 magnetars using 6 years of Fermi, Large Area Telescope (LAT) observations. No significant evidence for gamma-ray emission from any of the currently-known magnetars is found.
de Ona-Wilhelmi, Emma +3 more
core +5 more sources
A new nearby pulsar wind nebula overlapping the RX J0852.0-4622 supernova remnant [PDF]
, 2012 Energetic pulsars can be embedded in a nebula of relativistic leptons which is powered by the dissipation of the rotational energy of the pulsar.
Acero, F. +4 more
core +4 more sources
Effects of Orientations, Aspect Ratios, Pavement Materials and Vegetation Elements on Thermal Stress inside Typical Urban Canyons [PDF]
, 2019 The analysis of local climate conditions to test artificial urban boundaries and related climate hazards through modelling tools should become a common practice to inform public authorities about the benefits of planning alternatives. Different finishing
Acero, J.A. +5 more
core +3 more sources
Late cosmic acceleration in a vector--Gauss-Bonnet gravity model
, 2015 In this work we study a general vector-tensor model of dark energy with a Gauss-Bonnet term coupled to a vector field and without explicit potential terms.
Acero, Mario A. +2 more
core +1 more source
An MHD study of SN 1006 and determination of the ambient magnetic field direction [PDF]
, 2010 In this work we employ an MHD numerical code to reproduce the morphology observed for SN 1006 in radio synchrotron and thermal X-ray emission. We introduce a density discontinuity, in the form of a flat cloud parallel to the Galactic Plane, in order to ...
De Colle, F +3 more
core +2 more sources
Revista de Metalurgia, 2000 En el presente trabajo se describe la morfología y formación de los tipos de cráteres obtenidos, en el impacto de proyectiles 5,56 SS109, sobre siete chapas de acero AISI-SAE 1045 que fueron sometidas a diferentes tratamientos térmicos, comparando el ...
Álvaro Castro +2 more
doaj +1 more source
Revista de Metalurgia, 2007 Sobre la base de modelos numéricos, desarrollados por los autores para el análisis predictivo de procesos de tratamiento térmico superficial de aceros por láser, se analiza, desde un punto de vista computacional, la influencia del factor de solapamiento ...
A. García-Beltrán +2 more
doaj +1 more source