Results 21 to 30 of about 303,159 (255)

A Physiologically Based Pharmacokinetic Model Relates the Subcutaneous Bioavailability of Monoclonal Antibodies to the Saturation of FcRn-Mediated Recycling in Injection-Site-Draining Lymph Nodes

Antibodies
The bioavailability of a monoclonal antibody (mAb) or another therapeutic protein after subcutaneous (SC) dosing is challenging to predict from first principles, even if the impact of injection site physiology and drug properties on mAb bioavailability ...
Felix Stader, Cong Liu, Abdallah Derbalah, Hiroshi Momiji, Xian Pan, Iain Gardner, Masoud Jamei, Armin Sepp   +7 more
doaj   +1 more source

PROPIEDADES Y CAPACIDADES DE LOS TUBOS ESTRUCTURALES LAMINADOS EN FRÍO Y PRODUCIDOS EN COSTA RICA

Ingeniería, 2013
En este artículo se presentan los resultados de los cálculos hechos por la autora con el propósito de facilitar los diseños de las estructuras hechas en tubos estructurales.
Marija Romanjek Blimel
doaj   +1 more source

Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework

Pharmaceutics
Background/Objectives: Plasma levels of 4β-hydroxycholesterol (4β-OHC), a CYP3A-specific metabolite of cholesterol, are elevated after administration of CYP3A inducers like rifampicin and carbamazepine.
Aneesh V. Karkhanis, Matthew D. Harwood, Felix Stader, Frederic Y. Bois, Sibylle Neuhoff   +4 more
doaj   +1 more source

Valores de la constante B del método de resistencia de polarización para veinte sistemas metal-medio diferentes

Revista de Metalurgia, 1996
En una investigación sobre las posibilidades de aplicación de las técnicas electroquímicas a pie de obra, se utilizaron los métodos de resistencia de polarización y de intersección, sobre pequeñas probetas en el laboratorio, como procedimientos de ...
J. A. González, J. Albéniz, S. Feliu
doaj   +1 more source

Accelerating Biologics PBPK Modelling with Automated Model Building: A Tutorial

Pharmaceutics
Physiologically based pharmacokinetic (PBPK) modelling for biologics, such as monoclonal antibodies and therapeutic proteins, involves capturing complex processes, including target-mediated drug disposition (TMDD), FcRn-mediated recycling, and tissue ...
Abdallah Derbalah, Tariq Abdulla, Mailys De Sousa Mendes, Qier Wu, Felix Stader, Masoud Jamei, Iain Gardner, Armin Sepp   +7 more
doaj   +1 more source

Algunas influencias de la composición química sobre la viscosidad de las escorias sintéticas usadas en la colada continua del acero

Revista de Metalurgia, 2005
La calidad de productos semiacabados de la colada continua está influenciada, en gran parte, por el proceso de lubricación de la matriz que, a su vez, está influenciado por la viscosidad de escoria que resulta de la colada de polvos de fundición.
T. Heput, E. Ardelean, I. Kiss
doaj   +1 more source

Detection of TeV emission from the intriguing composite SNR G327.1-1.1

, 2011
The shock wave of supernova remnants (SNRs) and the wind termination shock in pulsar wind nebula (PWNe) are considered as prime candidates to accelerate the bulk of Galactic cosmic ray (CR) ions and electrons.
Acero, F., Djannati-Ataï, A., Förster, A., Gallant, Y., Renaud, M.   +4 more
core   +1 more source

Characterization of Multimodality in Wind Farm Layout Optimization

Energy Science &Engineering, EarlyView.
ABSTRACT The phenomena of multiple optima in wind farm layout optimization (WFLO) problems is investigated. The choice of optimization algorithm and cost of solving WFLO problems is driven by the degree of local optimality in the design space; however little work has attempted to characterize this.
Daniel J. Poole
wiley   +1 more source

Recovery from severe mental illness in the family: The role of intrapersonal and interpersonal differentiation

Family Relations, EarlyView.
Abstract Background Limited attention has been given to conceptualizing and examining what can help parents of adult children with mental illness recover from the impact of the illness on their relationship with their adult child. The concept of differentiation can serve as a means of exploring their recovery.
Netta Galmidi, Ron Shor
wiley   +1 more source

Control de la formación de fases en la soldadura fuerte de Al/Fe mediante haz láser Nd:YAG

Revista de Metalurgia, 2006
La reducción en el consumo de combustibles fósiles y las emergentes leyes mundiales anti-contaminación, obligan a prever una reducción en el peso de los vehículos de transporte.
L. Rodriguez, A. Mathieu, C. Langlade, A. Vannes   +3 more
doaj   +1 more source