Results 61 to 70 of about 7,268 (257)

Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview

Chemistry – A European Journal, EarlyView.
The graphical abstract summarizes the review “Pd(II)‐Catalyzed Strategies for the β‐Arylation of α‐Amino Acids: An Overview”, highlighting representative Pd(II)‐catalyzed methods for the β‐arylation of α‐amino acids. Key mechanistic features, substrate diversity, and synthetic relevance of these transformations are showcased. Abstract Metal‐catalyzed C─
Davide Illuminati, Claudio Trapella, Vinicio Zanirato, Virginia Cristofori, Anna Fantinati   +4 more
wiley   +1 more source

Approach for the synthesis of N-phenylamides from β-ketobutylanilides using dimethylformamide and dimethylacetamide as the acyl donors

Journal of Saudi Chemical Society, 2015
A new method including the sequence of a CN bond formation of β-keto amides with N,N-dimethylamides and subsequently another two CN bonds cleavage has been developed in the presence of hydrochloric acid.
Cui Chen, Liquan Tan, Peng Zhou
doaj   +1 more source

Serotonin 5-HT4 Agonist Activity of a Series of Meso-Azanoradamantane Benzamides [PDF]

, 1997
A series of meso-amino(methyl)azanoradamantane benzamides has been prepared and evaluated for 5-HT4agonism activity in the rat tunica muscularis mucosae (TMM) assay.
Becker, Daniel, Gullikson, Gary, Nosal, Roger, Villamil, Clara I.   +3 more
core   +1 more source

2-(4-Chlorophenyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
In the title compound, C(8)H(8)ClNO, the acetamide group is twisted out the benzene plane with a dihedral angle of 83.08 (1)°. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, forming layers parallel to the ab plane.
Dong-Sheng Ma, Pei-Jiang Liu, Shuai Zhang, Guang-Feng Hou   +3 more
openaire   +3 more sources

Methyl on the Bridge: 2‐Methyl Propellane as Precursor for 1,3‐Substituted 2‐Methylated Bicyclo[1.1.1]Pentanes

Chemistry – A European Journal, EarlyView.
The synthesis of 2‐methyl propellane and its conversion to various 1,2‐ and 1,2,3‐di‐ and trisubstituted bicyclopentanes is reported. Abstract Bicyclo[1.1.1]pentanes (BCPs) have emerged as isosteric replacements for mono‐ and para‐substituted benzene rings in medicinal and materials applications, involving substitution at the BCP bridgehead (1,3 ...
Sean R. Verschaeve, Mariana Gomes Manso, Tibo Van Eeckhoorn, Mark E. Light, Bruno Linclau   +4 more
wiley   +1 more source

Complementary regioselectivity in the synthesis of iminohydantoins: remarkable effect of amide substitution on the cyclization [PDF]

, 2013
Complementary regioselective synthesis of iminohydantoins from isocyanoacetamides controlled by the substituent on the amide group has been described.
García Valverde, María, González Ortega, Alfonso ., Marcaccini, Stefano ., Rodríguez Vidal, Francisco Javier, Rojo Cámara, Mª Josefa, Torroba Pérez, Tomás   +5 more
core   +1 more source

N-(3-Chlorophenyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
The conformation of the N-H bond in the structure of the title compound (3CPA), C(8)H(8)ClNO, is anti to the meta-chloro substituent, in contrast to the syn conformation observed for the ortho-chloro substituent in N-(2-chloro-phen-yl)acetamide, syn to both the ortho and meta chloro substituents in N-(2,3-dichloro-phen-yl)acetamide, and syn to the ...
Hartmut Fuess, Sabine Foro, B. Thimme Gowda   +2 more
openaire   +3 more sources

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, EarlyView.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Dizajniranje i sinteza novih derivata tiofenkarbohidrazida, tienopirazola i tienopirimidina s antioksidativnim i antitumorskim djelovanjem [PDF]

, 2010
2-Amino-5-acetyl-4-methyl-thiophene-3-carboxylic acid ethyl ester (1) and 5-acetyl-2-amino-4-methylthiophene-3-carbohydrazide (2) were synthesized and used as starting materials for the synthesis of new series of 1-(5-amino-4-(3,5-dimethyl-1H-pyrazole-1 ...
A. El-Gazzar, A. El-Gazzar, A. El-Gazzar, A. Rosowsky, Ameen Abu-Hashem, E. Lissi, Farid Badria, G. Nikolakopoulos, H. Hafez, H. Lütjens, I. Heiba, K. Dore, K. Gewald, K. Ghakraborti, L. Aurelio, M. Nassan, Mohamed El-Shehry, R. Aeschlach, R. Jarvest, S. Sasaki, T. Brown, T. Fujita, V. Alagarsamy, W. Lichen, Y. Morimoto   +24 more
core   +3 more sources

N-(2,3-Dimethylphenyl)acetamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
The conformation of the N-H bond in the structure of the title compound, C(10)H(13)NO, is syn to both the 2- and 3-methyl substituents on the aromatic ring, and is anti to the C=O bond. N-H⋯O hydrogen bonds link the mol-ecules into supra-molecular chains.
Hartmut Fuess, Hiromitsu Terao, Sabine Foro, B. Thimme Gowda   +3 more
openaire   +3 more sources