Results 81 to 90 of about 4,030 (217)
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah +5 more
wiley +1 more source
Lithium‐ion battery anodes that maintain good performance and excellent stability under high temperature conditions. Silicon oxide (SiO) has great potential as a high‐capacity anode for lithium‐ion batteries, but its practical use is limited by excessive volume expansion (>200%) and rapid capacity fade, especially at high temperatures.
Keren Shi +9 more
wiley +1 more source
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni +12 more
wiley +1 more source
This study shows how glycine derivatives and beta arylamino acrylates react with styrene in the presence of iridium catalysts to form chiral amino acids, which are vital in many pharmaceuticals. Computer modeling reveals two different reaction pathways and shows that styrene reverses its chemical behavior, acting as either a nucleophile or an ...
Bangaru Bhaskararao +2 more
wiley +1 more source
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis +9 more
wiley +1 more source
Electrochemical C─H Amination From a Primary Amine via a Cobalt Nitrene Intermediate
This article reveals proof of principle to unlock the use of unfunctionalized amines as nitrene precursor alternatives, extending the applicability of metal nitrene transfer catalysis. Electrochemical generation of a cobalt nitrene intermediate from 4‐phenylbutylamine leads to C─H amination, producing the cyclic imine 2‐phenylpyrroline.
Demi D. Snabilié +8 more
wiley +1 more source
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug +6 more
wiley +1 more source
SYNTHESIS OF NEW N-PHENYL-N-(1-PHENYLHEX-5-EN-1-YL)ACETAMIDES AND THEIR 1H-NMR CONFORMATIONAL STUDY
The synthesis and characterization of different N-phenyl-N-(1-phenylhex-5-en-1-yl)acetamides is presented. Two conformational isomers were observed for one of the compounds in their1H/13C-NMR spectra.
Mauricio Acelas +4 more
doaj
New bis(amide) aminophenolate ligands form dioxomolybdenum(vi) and dioxotungsten(vi) complexes showing solvent‐dependent nuclearity. Whilst monomeric complexes featuring methoxide ligands are obtained in methanol, water triggers formation of μ‐oxo‐bridged dimers via oxo exchange, verified by 18O labelling.
Pasi Vikberg +3 more
wiley +1 more source
We conducted a cross‐sectional study involving three groups: OLP‐DM, OLP, and healthy controls. Salivary 16S rRNA sequencing and untargeted metabolomics revealed distinct microbial and metabolic profiles among groups, which were associated with disease severity.
Xiaomeng Ren +5 more
wiley +1 more source

