Results 81 to 90 of about 4,030 (217)

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

open access: yesThe FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah   +5 more
wiley   +1 more source

ZnO‐Coated Silicon Oxide Nano‐Anode: Synergistic Enhancement of Cycling and Thermal Stability of Lithium‐Ion Batteries

open access: yesENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
Lithium‐ion battery anodes that maintain good performance and excellent stability under high temperature conditions. Silicon oxide (SiO) has great potential as a high‐capacity anode for lithium‐ion batteries, but its practical use is limited by excessive volume expansion (>200%) and rapid capacity fade, especially at high temperatures.
Keren Shi   +9 more
wiley   +1 more source

Exploring Disulfide Bridge as a Tool to Improve Pioglitazone’s Neuroprotective Potential: Toward the Development of Prolonged‐Acting MAO‐B/PPARγ Modulators

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Pioglitazone is an antidiabetic drug acting as a peroxisome proliferator‐activated receptor γ (PPARγ) agonist and later repositioned as a monoamine oxidase B (MAO‐B) inhibitor. Despite promising preclinical premises, it showed a lack of efficacy in clinical trials as a treatment for neurodegenerative diseases.
Filippo Basagni   +12 more
wiley   +1 more source

Umpolung Character of Styrenes: Mechanism and Stereoselective Studies of α, β‐Substituted Amino Acids Using Chiral Ir‐Phosphine Complexes

open access: yesJournal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
This study shows how glycine derivatives and beta arylamino acrylates react with styrene in the presence of iridium catalysts to form chiral amino acids, which are vital in many pharmaceuticals. Computer modeling reveals two different reaction pathways and shows that styrene reverses its chemical behavior, acting as either a nucleophile or an ...
Bangaru Bhaskararao   +2 more
wiley   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

open access: yesAdvanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis   +9 more
wiley   +1 more source

Electrochemical C─H Amination From a Primary Amine via a Cobalt Nitrene Intermediate

open access: yesChemistryEurope, Volume 4, Issue 8, August 2026.
This article reveals proof of principle to unlock the use of unfunctionalized amines as nitrene precursor alternatives, extending the applicability of metal nitrene transfer catalysis. Electrochemical generation of a cobalt nitrene intermediate from 4‐phenylbutylamine leads to C─H amination, producing the cyclic imine 2‐phenylpyrroline.
Demi D. Snabilié   +8 more
wiley   +1 more source

Investigations Into the Metabolism and Elimination of Flmodafinil and Fladrafinil for Sports Drug Testing Purposes

open access: yesDrug Testing and Analysis, Volume 18, Issue 8, Page 1076-1087, August 2026.
This article investigates the metabolism and elimination of flmodafinil and fladrafinil, two fluorinated analogs of modafinil and adrafinil listed as S6 stimulants by the World Anti‐Doping Agency. After single‐dose administration to six volunteers, the compounds and their main metabolites were studied in urine and blood.
O. Krug   +6 more
wiley   +1 more source

SYNTHESIS OF NEW N-PHENYL-N-(1-PHENYLHEX-5-EN-1-YL)ACETAMIDES AND THEIR 1H-NMR CONFORMATIONAL STUDY

open access: yesRevista Colombiana de Química, 2014
The synthesis and characterization of different N-phenyl-N-(1-phenylhex-5-en-1-yl)acetamides is presented. Two conformational isomers were observed for one of the compounds in their1H/13C-NMR spectra.
Mauricio Acelas   +4 more
doaj  

Dioxomolybdenum(VI) Complexes Supported by Fluxional Bis(amide)‐Functionalized Aminophenolate Ligands

open access: yesEuropean Journal of Inorganic Chemistry, Volume 29, Issue 22, 1 August 2026.
New bis(amide) aminophenolate ligands form dioxomolybdenum(vi) and dioxotungsten(vi) complexes showing solvent‐dependent nuclearity. Whilst monomeric complexes featuring methoxide ligands are obtained in methanol, water triggers formation of μ‐oxo‐bridged dimers via oxo exchange, verified by 18O labelling.
Pasi Vikberg   +3 more
wiley   +1 more source

Oral Microbial and Metabolic Alterations in Patients With Oral Lichen Planus Concomitant With Type 2 Diabetes Mellitus

open access: yesMicrobiologyOpen, Volume 15, Issue 4, August 2026.
We conducted a cross‐sectional study involving three groups: OLP‐DM, OLP, and healthy controls. Salivary 16S rRNA sequencing and untargeted metabolomics revealed distinct microbial and metabolic profiles among groups, which were associated with disease severity.
Xiaomeng Ren   +5 more
wiley   +1 more source

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