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Acetaminophen and asthma

Paediatric Respiratory Reviews, 2013
Acetaminophen is a widely used medication for the treatment of pain and fever in children and pregnant women. There is substantial epidemiological evidence in adults and children that acetaminophen use is associated with asthma symptoms. There is also a considerable body of evidence that supports a modest but consistent association of acetaminophen use
A John, Henderson, Seif O, Shaheen
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Acetaminophen Poisoning

Clinics in Laboratory Medicine, 2006
Acetaminophen (acetyl-para-amino-phenol or APAP), an antipyretic and analgesic, is a common component in hundreds of over-the-counter and prescription medications. The wide usage of this drug results in many potentially toxic exposures. It is therefore critical for the clinician to be comfortable with the diagnosis and treatment of APAP toxicity ...
Adam K, Rowden   +3 more
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Acetaminophen Toxicity

Orthopaedic Nursing, 1997
Acetaminophen is the most widely used and recommended nonprescription analgesic and antipyretic medication in the United States (Rose, 1994). Because acetaminophen is widely advertised and readily available over the counter, consumers as well as health care professionals perceive this medication to be nontoxic.
J A, Roach, B, Stacey
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Acetaminophen Overdose

Emergency Medicine Clinics of North America, 1984
N-acetylcysteine (NAC) is the treatment of choice for acetaminophen overdose. With this therapy, morbidity from overdose can be held to a minimum. Mortality is rare in any case and virtually nonexistent in treated patients. Unless a high index of suspicion is maintained, the diagnosis may be missed until it is too late for effective antidotal treatment.
C H, Linden, B H, Rumack
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Dosage of Acetaminophen

JAMA: The Journal of the American Medical Association, 1983
To the Editor.— All physicians who treat children should be alerted to the fact that large numbers of mothers are purchasing acetaminophen as Tylenol Elixir and administering it to their infants with the dropper that comes with the Tylenol Infant Drops.
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Acetaminophen Hepatotoxicity

Digestive Diseases and Sciences, 2000
To determine the influence of psychosocial factors in accidental and deliberate acetaminophen overdose, we reviewed the charts of 207 overdose patients, and 48 met our criteria for acetaminophen toxicity. Two patients died. A psychiatric history was present in 75%, and 25% had a previous or subsequent suicide attempt.
T A, Broughan, R D, Soloway
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Contribution of acetaminophen-cysteine to acetaminophen nephrotoxicity in CD-1 mice: I. Enhancement of acetaminophen nephrotoxicity by acetaminophen-cysteine

Toxicology and Applied Pharmacology, 2005
Acetaminophen (APAP) nephrotoxicity has been observed both in humans and research animals. Recent studies suggest a contributory role for glutathione (GSH)-derived conjugates of APAP in the development of nephrotoxicity. Inhibitors of either gamma-glutamyl transpeptidase (gamma-GT) or the probenecid-sensitive organic anion transporter ameliorate APAP ...
Stephan T, Stern   +5 more
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Acetaminophen by Infusion

Orthopaedic Nursing, 2015
Acetaminophen is a nonsteroidal, nonsalicylate analgesic and antipyretic that is, today, the most common medication ingredient found in oral and rectal over-the-counter and prescription drugs. However, it was not until 2010 that Ofirmev (acetaminophen), an injection form of acetaminophen, was approved for treating mild to moderate pain, as an adjunct ...
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Acetaminophen Hepatotoxicity

Clinics in Liver Disease, 2007
Acetaminophen is a commonly used antipyretic and analgesic agent. It is safe when taken at therapeutic doses; however, overdose can lead to serious and even fatal hepatotoxicity. The initial metabolic and biochemical events leading to toxicity have been well described, but the precise mechanism of cell injury and death is unknown. Prompt recognition of
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ACETAMINOPHEN POISONING

Pediatrics, 1973
Acetaminophen* is being increasingly used as a mild analgesic/antipyretic both as a replacement for phenacetin and as a substitute for aspirin. In Britain the current consumption of acetaminophen has been estimated to be about 50% of that of aspirin, which in turn has been calculated to be the equivalent of 6,000 million tablets per year.1
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