Results 111 to 120 of about 29,036 (224)

CA IX Inhibition by a Sulfonamide Compound: A Therapeutic Approach Against Breast Cancer

open access: yesChemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Synergistic Efficacy of MMH‐I and 5‐Fluorouracil Combination Therapy in CA IX‐Expressing Breast Cancer Models: Pathological and Metabolic Insights. ABSTRACT Carbonic anhydrase IX (CA IX) is overexpressed in many solid tumors, contributing to cancer cell proliferation, survival, invasion, and metastasis.
Sükrü Akmese   +7 more
wiley   +1 more source

Long-Term Outcome of Juvenile Myoclonic Epilepsy

open access: yesPediatric Neurology Briefs, 2014
Investigators at Epilepsy Centers in Berlin, Germany, performed a retrospective study of seizure outcome in 66 patients with juvenile myoclonic epilepsy (JME) after a mean follow-up time of 44.6 years (20-69 years); 59.1% of patients remained seizure ...
J Gordon Millichap
doaj   +1 more source

Neuroprotective and Renoprotective Potential of a Hydroethanolic Extract From the Aerial Parts of Mattiastrum paphlagonicum Bornm. (Boraginaceae)

open access: yesChemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT This study provides an analysis of the endemic plant Mattiastrum paphlagonicum Bornm.(Synonym Paracaryum paphlagonicum (Bornm.) R.R. Mill), focusing on enzyme activity, secondary metabolite content, antioxidant capacity (DPPH, ABTS, and FRAP), as well as phenolic and flavonoid levels, all within the context of a hydroethanolic extract prepared
Ayşenur Kayabaş Avşar   +4 more
wiley   +1 more source

Assessment of oral acetazolamide on postoperative pain after laparoscopic cholecystectomy [PDF]

open access: yes, 2010
Background and aim: Carbon dioxide (Co2) is used during laparoscopy for producing pneumoperttoneum. Combination of this gas with irrigation fluid in the abdomen produces carbonic acid which creates two kinds of abdominal and referred pain to right ...
Moazeni-Bistgani, M.   +2 more
core  

Cerebral Venous Outflow Insufficiency: A Study on Symptoms and Venous Stenosis Classification

open access: yesMedComm, Volume 7, Issue 3, March 2026.
Cerebral venous outflow insufficiency (CVOI) predominantly consists of 10 cerebral venous congestion symptoms. Based on the traditional classification according to imaging features, this study classified CVOI into intracranial (CV), extracranial (JV), and tandem (CJV) types, which better reflect the imaging features and pathological types of patients ...
Hui Li   +10 more
wiley   +1 more source

Pharmacologic Treatment of Kleine–Levin Syndrome: A Case Report and Comprehensive Review of Therapeutic Options

open access: yesNeuropsychopharmacology Reports, Volume 46, Issue 1, March 2026.
A 12‐year‐old girl with Klein‐Levin syndrome showed central hypopneas and REM sleep without atonia on 24‐h polysomnography, which normalized after clarithromycin treatment alongside clinical remission. ABSTRACT Kleine–Levin syndrome (KLS) is a rare disorder with limited literature on treatment options and efficacy, especially in adolescents.
Sarisa Thawongit   +2 more
wiley   +1 more source

Effect of nocturnal oxygen and acetazolamide on exercise performance in patients with pre-capillary pulmonary hypertension and sleep-disturbed breathing: randomized, double-blind, cross-over trial [PDF]

open access: yes, 2017
Aim Sleep-disturbed breathing (SDB) is common in pre-capillary pulmonary hypertension (PH) and impairs daytime performance. In lack of proven effective treatments, we tested whether nocturnal oxygen therapy (NOT) or acetazolamide improve exercise ...
Bloch, Konrad E.   +7 more
core  

Clinical outcomes of the PAUL glaucoma implant in primary open‐angle and pseudoexfoliative glaucoma eyes after failed glaucoma surgeries

open access: yesActa Ophthalmologica, Volume 104, Issue 2, Page e183-e190, March 2026.
Abstract Purpose This study assesses the PAUL® glaucoma implant (PGI) in primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) after failed glaucoma surgery. Given PEXG's more aggressive nature, limited research exists on PGI outcomes in this subgroup. This study aims to compare PGI's efficacy and safety in both conditions. Methods A
Constance Liegl   +8 more
wiley   +1 more source

Identifying Drugs Associated With Parkinson's Disease Risk Using Machine Learning

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Machine learning (ML)–based methods have been proposed as a potential approach for identifying candidate drugs to be repurposed as disease‐modifying treatments for Parkinson's disease (PD). We applied an ML‐based signal detection method to identify drugs associated with PD and evaluated the method's generalizability.
Eeva Pylkkö   +8 more
wiley   +1 more source

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