Results 31 to 40 of about 29,225 (214)

Ataxia in children: early recognition and clinical evaluation [PDF]

, 2017
Background: Ataxia is a sign of different disorders involving any level of the nervous system and consisting of impaired coordination of movement and balance.
Falsaperla, Raffaele, Lubrano, Riccardo, Pavone, Piero, Pavone, Vito, Praticò, Andrea D., Rizzo, Renata, Ruggieri, Martino   +6 more
core   +1 more source

Effect of 5 weeks of oral acetazolamide on patients with pulmonary vascular disease: A randomized, double-blind, cross-over trial

Pulmonology
Background The carbonic anhydrase inhibitor acetazolamide stimulates ventilation through metabolic acidosis mediated by renal bicarbonate excretion. In animal models, acetazolamide attenuates acute hypoxia-induced pulmonary hypertension (PH), but its ...
M. Lichtblau, S. Saxer, J. Müller, P. Appenzeller, C. Berlier, S.R. Schneider, L. Mayer, M. Furian, E.I. Schwarz, E.R. Swenson, K.E. Bloch, S. Ulrich   +11 more
doaj   +1 more source

Efficacy of Acetazolamide in Refractory Epilepsy Management: A Quasi-Experimental Study

Pakistan Armed Forces Medical Journal, 2023
Objective: To assess the efficacy of Acetazolamide in refractory epilepsy management. Study Design: Quasi-experimental study. Place and Duration of Study: Outpatient Neurology Department, Allied Hospital, Faisalabad Pakistan, from Sep 2020 to Feb ...
Muhammad Ahmed Zamir, Naveed Alam, Javed Iqbal, Muhammad Ali Rehman, Baqar Raza   +4 more
doaj   +1 more source

Cognitive function and mood at high altitude following acclimatization and use of supplemental oxygen and adaptive servoventilation sleep treatments. [PDF]

, 2019
Impairments in cognitive function, mood, and sleep quality occur following ascent to high altitude. Low oxygen (hypoxia) and poor sleep quality are both linked to impaired cognitive performance, but their independent contributions at high altitude remain
Anza-Ramirez, Cecilia, Bosompra, Naa-Oye, DeYoung, Pamela N, Djokic, Matea A, Gilbertson, Dillon, Heinrich, Erica C, Malhotra, Atul, Orr, Jeremy E, Powell, Frank L, Simonson, Tatum S, Wu, Lu   +10 more
core   +2 more sources

Rebound macular edema following oral acetazolamide therapy for juvenile X-linked retinoschisis in an Italian family [PDF]

, 2016
BACKGROUND: Juvenile X-linked retinoschisis (RS1, OMIM: 312700) is a hereditary vitreoretinal dystrophy characterized by bilateral foveal schisis and, in half of the patients, splitting through the nerve fiber layer in the peripheral retina. In the first
CUCCU, ALBERTO, FARCI, ROBERTA, FOSSARELLO, MAURIZIO, GALANTUOMO, MARIA SILVANA, Lorenz, B, NAPOLI, PIETRO EMANUELE, Preising, MN   +6 more
core   +2 more sources

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Preparation of acetazolamide composite microparticles by supercritical antisolvent techniques [PDF]

, 2007
The possibility of preparation of ophthalmic drug delivery systems using compressed anti-solvent technology was evaluated. and RL 100 were used as drug carriers, acetazolamide was the model drug processed.
Duarte, Ana Rita C., Duarte, Catarina M. M., Gonzalez, A. V., Roy, C., Subra-Paternault, Pascale   +4 more
core   +1 more source

Anti‐Obesity Pharmacotherapy and Emerging Multimodal Interventions for Obstructive Sleep Apnea

Chronic Diseases and Translational Medicine, EarlyView.
Cellular and molecular mechanisms of obesity‐related obstructive sleep apnea (OSA). ADMA: asymmetric dimethyrarginine, NLRP3: nucleotide‐binding domain, leucine‐rich repeat family, Pyrin domain containing 3, TLR: toll‐like receptors, IL‐1β: interleukin‐1β, IL‐6: interleukin‐6; LPS: lipopolysacharide, ROS: reactive oxygen species, TNF‐α.
Anish Preshy, Cornelius J. Fernandez, Mohammad Hamid Nedai, Joseph M. Pappachan   +3 more
wiley   +1 more source

Effects of Acetazolamide on Collagen Metabolism in Keratoconus Fibroblasts

Taiyuan Ligong Daxue xuebao, 2023
Keratoconus is characterized by the progressive thinning and protrusion of central cornea. Dysregulated collagen metabolism is one of the causes of this disease.
Yunpeng XIE, Xuqin LEI, Jie SONG, Xiaona LI, Rui HE, Jizhong YANG, Pengfei FENG   +6 more
doaj   +1 more source