Results 21 to 30 of about 22,014 (216)

The Effects of Acetazolamide on Cerebral Hemodynamics in Adult Patients with an Acute Brain Injury: A Systematic Review

Brain Sciences, 2023
Background: Acetazolamide is a non-competitive inhibitor of carbonic anhydrase, an enzyme expressed in different cells of the central nervous system (CNS) and involved in the regulation of cerebral blood flow (CBF).
Claudia Stella, Anas Hachlouf, Lorenzo Calabrò, Irene Cavalli, Sophie Schuind, Elisa Gouvea Bogossian, Fabio Silvio Taccone   +6 more
doaj   +1 more source

Acclimatizing with Acetazolamide [PDF]

Journal of Travel Medicine, 2012
Although it is best to prevent acute mountain sickness (AMS) 1 by gradual ascent without using any drugs, this may not always be an option in many settings. Rescuers may need to go up rapidly to high altitudes; or logistically, owing to a lack of camp site, it may not be possible for trekkers and climbers to spend the night at an optimal altitude ...
openaire   +2 more sources

Acetazolamide-based fungal chitinase inhibitors [PDF]

, 2010
Chitin is an essential structural component of the fungal cell wall. Chitinases are thought to be important for fungal cell wall remodelling, and inhibition of these enzymes has been proposed as a potential strategy for development of novel anti-fungals.
Gros, Ludovic, van Aalten, Daan M. F., Schuettelkopf, Alexander W., David E. Blair, van Aalten, Daan M.F., Blair, David E., Frearson, Julie A., Schüttelkopf, Alexander W., Daan M.F. van Aalten, Ian H. Gilbert, Gilbert, Ian H., Julie A. Frearson, Alexander W. Schüttelkopf, Ludovic Gros   +13 more
core   +1 more source

Structural and Vibrational Study on Monomer and Dimer Forms and Water Clusters of Acetazolamide

Journal of Spectroscopy, 2013
Experimental IR and Raman spectra of solid acetazolamide have been analysed by computing the molecular structures and vibrational spectra of monomer and dimer forms and water clusters of acetazolamide. The possible stable conformers of free acetazolamide
Aysen E. Ozel, Serda Kecel Gunduz, Sefa Celik, Sevim Akyuz   +3 more
doaj   +1 more source

Should I Stay or Should I Go—Leveraging an Overlooked Feature of Click‐to‐Release Chemistry for Affinity Labeling

Angewandte Chemie, EarlyView.
Click‐to‐release (C2R) chemistry is redirected from payload liberation toward ligand‐directed covalent protein labeling through a transient dihydropyridazine methide (DHP‐methide). This concept opens the way to dual‐functional systems combining covalent target engagement with controlled effector release.
Dóra Kern, Krisztina Németh, Tímea Imre, József Simon, Kitti Meggyes, Gergő Bárdos, László Petri, Márton Bojtár, Attila Kormos, Péter Kele   +9 more
wiley   +2 more sources

Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Neisseria gonorrhoeae is a high-priority pathogen of concern due to the growing prevalence of resistance development against approved antibiotics. Herein, we report the anti-gonococcal activity of ethoxzolamide, the FDA-approved human carbonic anhydrase ...
Nader S. Abutaleb, Ahmed E. M. Elhassanny, Alessio Nocentini, Chad S. Hewitt, Ahmed Elkashif, Bruce R. Cooper, Claudiu T. Supuran, Mohamed N. Seleem, Daniel P. Flaherty   +8 more
doaj   +1 more source

Erythroid anion exchanger-1 (SLC4A1) modulates carbonic anhydrase inhibitor acetazolamide on respiration

Frontiers in Physiology
IntroductionClinically widely used acetazolamide is a potent carbonic anhydrase (CA) inhibitor. CA accelerates CO2(g)⇌HCO3-(aq) bidirectional conversion. CAII, the major functional isoform, primarily resides inside red blood cells (RBCs).
Cheng-Ta Lai, Cheng-Ta Lai, Jing-Heng Lin, Tian Hu, Hui-Lin Lee, Shih-Wei Wang, Shih-Wei Wang, Kate Hsu, Kate Hsu, Kate Hsu   +9 more
doaj   +1 more source

Cerebrovascular reserve in moyamoya disease: relation to cerebral blood flow, capillary dysfunction, oxygenation, and energy metabolism

Frontiers in Neurology, 2023
BackgroundCerebral hemodynamics in moyamoya disease (MMD) is complex and needs further elucidation. The primary aim of the study was to determine the association of the cerebrovascular reserve (CVR) with cerebral blood flow (CBF) disturbances, oxygen ...
Teodor Svedung Wettervik, Markus Fahlström, Johan Wikström, Anders Lewén, Per Enblad   +4 more
doaj   +1 more source

Acetazolamide Attenuates Lithium-Induced Nephrogenic Diabetes Insipidus [PDF]

, 2015
To reduce lithium-induced nephrogenic diabetes insipidus (lithium-NDI), patients with bipolar disorder are treated with thiazide and amiloride, which are thought to induce antidiuresis by a compensatory increase in prourine uptake in proximal tubules ...
Groot, T. de, Wetzels, J.F.M., Deen, P.M.T., Wetzels, Jack F, Olivier Devuyst, Mohammad Alsady, Deen, Peter M T, Sinke, Anne P, Baumgarten, Ruben, de Groot, Theun, Devuyst, Olivier, Devuyst, O., Marleen L.A. Kortenoeven, Kortenoeven, M.L.A., Johannes Loffing, Kortenoeven, Marleen L A, Sinke, A.P., Alsady, M., Loffing, J., Anne P. Sinke, Jack F. Wetzels, Ruben Baumgarten, Loffing, Johannes, Alsady, Mohammad, Theun de Groot, Peter M.T. Deen, Baumgarten, R.   +26 more
core   +2 more sources

Effects of acetazolamide on control of breathing in sleep apnea patients: Mechanistic insights using meta‐analyses and physiological model simulations

Physiological Reports, 2021
Obstructive and central sleep apnea affects ~1 billion people globally and may lead to serious cardiovascular and neurocognitive consequences, but treatment options are limited.
Christopher N. Schmickl, Shane Landry, Jeremy E. Orr, Brandon Nokes, Bradley A. Edwards, Atul Malhotra, Robert L. Owens   +6 more
doaj   +1 more source