Results 241 to 250 of about 199,012 (297)

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo, Kunzhao Huang, Xiaoyuan Yi, Pei Lu, Huaying Xie, Wen Li, Qingyu Zeng, Feifei He, Duo Wang, Liyan Wang   +9 more
wiley   +1 more source

Interactome Profiling of a Lysine Deacetylase Trapping Probe Library Uncovers Crosstalk Between HDAC6 and NF-κB Signaling. [PDF]

Angew Chem Int Ed Engl
Seidel J, Schönfeld C, Sindlinger J, Eirich J, Kirchgäßner S, Kreienkamp N, Schulze-Osthoff K, Finkemeier I, Hailfinger S, Schwarzer D.   +9 more
europepmc   +1 more source

SpaBalance: Balanced Learning for Efficient Spatial Multi‐Omics Decoding

Advanced Science, EarlyView.
SpaBalance is a computational framework that harmonizes multi‐omics learning via gradient equilibrium and dual‐stream feature decomposition, achieving superior clustering accuracy, biological interpretability, and scalable integration of three or more spatial omics modalities.
Yingbo Cui, Yong Zhao, Canqun Yang, Tao Tang, Xiangke Liao, Hongyu Zhang, Huiying Zhao, Zheng Wang, Yuansong Zeng   +8 more
wiley   +1 more source

Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli. [PDF]

Cell Mol Life Sci
Mohammed D, Hamid I, Vanhollebeke B, Martin M.   +3 more
europepmc   +1 more source

Extracellular Vesicle‐Packaged circTAX1BP1 from Cancer‐Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells

Advanced Science, EarlyView.
This study reveals that CAFs‐derived EVs enriched with circTAX1BP1 drive CRLM by promoting VIRMA lactylation and SP1/TGF‐β signaling, creating a positive feedback loop via ITGA11+ myCAFs. Targeting EV‐circTAX1BP1 and TGF‐β disrupts this loop, offering a novel therapeutic strategy for CRLM.
Jia‐nan Tan, Jin‐hao Yu, Dong Hou, Ye‐quan Xie, Dong‐ming Lai, Fang Zheng, Bin Yang, Jin‐tao Zeng, Yang Chen, Shu‐hong Lu, Guang‐yu Zhong, Fang‐hai Han, Sheng‐ning Zhou   +12 more
wiley   +1 more source

Streptococcus pneumoniae synchronizes the states of cell wall peptidoglycan acetylation and genome methylation by programmed DNA inversions. [PDF]

PLoS Pathog
Li XY, He P, Wang S, Wang Y, Yan D, Liu X, Deng H, Feng Z, Wang J, Zhang JR.   +9 more
europepmc   +1 more source

Computational and AI‐Driven Design of Hydrogels for Bioelectronic Applications

Advanced Electronic Materials, EarlyView.
This review highlights the role of AI in advancing hydrogel design for bioelectronics, exploring natural, and synthetic gels tailored for applications like wound healing, biosensing, and tissue engineering. It emphasizes the synergy between hydrogels, electronics, and AI in creating responsive, multifunctional systems, showcasing recent innovations ...
Rebekah Finster, Prashant Sankaran, Eloise Bihar   +2 more
wiley   +1 more source

Multi-omics protein signaling networks identify sex-specific therapeutic candidates in lung adenocarcinoma. [PDF]

Biol Sex Differ
Chen C, Saha E, Fischer J, Ben Guebila M, Fanfani V, Shutta KH, Padi M, Glass K, DeMeo DL, Lopes-Ramos CM, Quackenbush J.   +10 more
europepmc   +1 more source

The Mechanism and Potential Therapeutic Strategies of Vascular Aging

AGING MEDICINE, EarlyView.
The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu, Xuan Wang, Fang‐Fang Wu, Xiao‐Tian Yan, Yong‐Ping Bai   +4 more
wiley   +1 more source

From gut to proteomics: the impact of <i>Roseburia intestinalis</i> on post-translational modifications in colorectal cancer. [PDF]

Front Oncol
Li L, Zhang Y, Wu Q, Jin Z, Xia H, Wu H, Li K, Wang L.   +7 more
europepmc   +1 more source