Results 311 to 320 of about 374,029 (398)

A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage

open access: yesAngewandte Chemie, EarlyView.
This work advances methodology by addressing challenges in mimicking the complex in vivo spatial relationships of histone acetylation and DNA damage. The combination of an abiotic/enzymatic hybrid catalyst system (ABEHCS) and the plug‐and‐play method has constituted a versatile platform to construct nucleosome arrays with precise histone acetylation ...
Ziyun Liu   +6 more
wiley   +2 more sources

The multilayered control of acetylation during adenovirus-based immunotherapy of cancer. [PDF]

open access: yesMol Ther Oncol
Parthasarathy A   +5 more
europepmc   +1 more source

Acyl post-translational modification of proteins by metabolites in cancer cells. [PDF]

open access: yesCell Death Discov
Wang X   +9 more
europepmc   +1 more source

Decoding the Chemical Language of Ribosomally Synthesized and Post‐Translationally Modified Peptides from the Untapped Archaea Domain

open access: yesAngewandte Chemie, EarlyView.
Secondary metabolites (SMs) are essential across all life domains, yet those originating from the Archaea domain remain poorly understood. Here, the systematic genome mining and the pioneering heterologous expression of archaeal SMs have revealed the chemical landscape of archaeal lanthipeptides, showing both canonical and non‐canonical forms.
Zhi‐Man Song   +13 more
wiley   +2 more sources

Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis

open access: yesHepatology, 2017
Hongli Hu   +13 more
semanticscholar   +1 more source

Unnatural Triggers Converted From Tetrazine‐Attached Sialic Acid for Activation of Optoacoustic Imaging‐Guided Cancer Theranostics

open access: yesAngewandte Chemie, EarlyView.
Tetrazine precursors (SiaTz) based on a nonO‐acetylated sialic acid scaffold are rationally designed and synthesized, which can be efficiently converted into unnatural tetrazine (Tz) triggers on cancer cell surfaces via metabolic glycoengineering. These Tz triggers activate theranostic agents for multispectral optoacoustic tomographic (MSOT) imaging ...
Yinglong Wu   +15 more
wiley   +2 more sources

Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders. [PDF]

open access: yesGenes (Basel)
Martínez-Iglesias O   +4 more
europepmc   +1 more source

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