Results 141 to 150 of about 227,192 (263)

Frontiers in transition‐metal single‐atom electrocatalysts: Design tactics, mechanistic regulation, and electrochemical sensing technologies

InfoMat, EarlyView.
This review offers an overview of recent advances in the fundamental properties, synthesis methods, and structural optimization of transition‐metal single‐atom electrocatalysts for electrochemical sensing. It also provides a comprehensive summary of the emerging applications in electrochemical assays based on these materials, along with key challenges ...
Yue Cao, Bo‐Yu Chen, Yiru Sheng, Haoyuan Song, Linan Zhu, Xiaohan Yang, Yuehe Lin, Wenlei Zhu, Yang Zhou   +8 more
wiley   +1 more source

A Biosensor for the Detection of Acetylcholine and Diazinon

, 2019
Acetylcholine is a neurotransmitter and a neuromodulator found in the autonomic, peripheral and central nervous systems. Diazinon is a pesticide with toxic effects on humans, such as the inhibition of acetylcholine. In this paper, a biosensor is proposed
P. Salvo, Poma N., Di Francesco F., D. Santalucia, F. Vivaldi, E. G. Herrera, A. Kirchhain, Herrera E. G., Kirchhain A., Melai B., Vivaldi F., Bonini A., F. Di Francesco, SANTALUCIA, DELIO, A. Bonini, B. Melai, Salvo P., N. Poma, Di Francesco F, Vivaldi F, Melai B, Bonini A, Santalucia D, Herrera E G, Kirchhain A, Salvo P, Poma N, Bonini, A.   +27 more
core   +1 more source

Organic electrochemical transistors for neural recording and modulation: From mixed‐conduction physics to closed‐loop biointerfaces

InfoMat, EarlyView.
OECT‐based neural interfaces integrate mixed ionic‐electronic transduction, soft biointegration, multimodal sensing, and closed‐loop modulation, enabling adaptive recording, neurochemical monitoring, and intelligent therapeutic strategies. Abstract Next‐generation neural interfaces increasingly aim to couple neural recording with local processing and ...
Chao Zhao, Zhongqing Sun, Shijie Wang, Bingjun Wang, Zixuan Yuan, Yaomin Guo, Jie Zhao, Leyuan Li, Xiaomu Wang, Wen Jiang, Wei Ma   +10 more
wiley   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Association of Neonicotinoid insensitivity with a conserved residue in the Loop D binding region of the Tick Nicotinic Acetylcholine Receptor

, 2012
Neonicotinoid insecticides target nicotinic acetylcholine receptors (nAChR) in the nervous system of insects but are largely ineffective against ticks. This study aimed to identify the molecular basis for this insensitivity. A homology model of the nAChR
O’Reilly, Andrias O., Field, L.M., Erdmanis, L., Field, L. M., Williamson, M.S., Wallace, Bonnie A., O'Reilly, A. O., Wallace, B. A., Turberg, A., Williamson, M. S., Williamson, Martin, Field, Lin   +11 more
core   +1 more source

Engineered 3D cultured human nasal mucosa mesenchymal stem cell derived sEVs for targeted brain‐derived neurotrophic factor delivery to enhance neurogenesis and attenuate brain damage

Interdisciplinary Medicine, EarlyView.
This study successfully developed and evaluated BDNF@RVG‐sEVs, a novel brain‐targeted nanomedicine based on hnmMSC‐derived sEVs, designed to overcome the BBB and enhance neurorestoration. By integrating RVG for enhanced brain targeting and encapsulating BDNF for potent neurorepair, our system address the key limitations of the conventional sEVs and ...
Xueting Wang, Junge Chen, Jiao Xia, Weitong Yang, Teng Ma, Tianzi Shan, Weifeng He, Gaoman Zhang, Zhuoran Xia, Weiwei Wang, Zhusheng Liu, Zhiqiang Yi, Piye Niu, Tian Chen   +13 more
wiley   +1 more source

Adverse Effects of Unsaturated Organic Compounds on Kinetic States During Locomotion Uncovered by Comprehensive Analysis of Behavioral Toxicities in C. elegans

Journal of Applied Toxicology, EarlyView.
ABSTRACT Organisms in human living spaces are surrounded by a variety of engineered substances. These chemical compounds have unexpected effects on the environment and human health. In particular, workers in industries face the risk of a health hazard caused by high‐dose or long‐term exposure to chemicals in the workplace.
Masahiro Tomioka
wiley   +1 more source

Cytotoxic and Oxidative Effects of Common Pesticides on Hepatic and Renal Cell Lines (HepG2 and Hek‐293): Implications for Human Health and Environmental Safety

Journal of Applied Toxicology, EarlyView.
ABSTRACT Modern agricultural practices expose humans and the environment to numerous chemical pesticides. Increasing evidence suggests that commercial pesticide formulations may exhibit toxicological properties that differ from those of their active ingredients alone due to the presence of co‐formulants and additives. This study evaluated the cytotoxic
Fares Elghali, Kawther Bedchich, Nour Kacem, Mohamed Sami Aifa   +3 more
wiley   +1 more source

Diaphragm Ultrasonography Reveals Progressive Changes in Diaphragmatic Function, Morphology, and Muscle Trophism During Invasive Mechanical Ventilation in Children

Journal of Clinical Ultrasound, EarlyView.
Diaphragm ultrasonography detected progressive structural and functional deterioration in mechanically ventilated children. Prolonged invasive mechanical ventilation and neuromuscular blocking agent use were associated with ventilator‐induced diaphragmatic dysfunction, highlighting ultrasound as a valuable bedside tool to support individualized ...
Juliana Bezerra dos Santos, Emmerson Carlos Franco de Farias, Mary Lucy Ferraz Maia Fiuza de Mello, Rodrigo Santiago Barbosa Rocha   +3 more
wiley   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source