Results 151 to 160 of about 343,067 (338)

Effects of geranylgeranylacetone on diastolic and microvascular function in patients with heart failure with a preserved ejection fraction: A phase 2, randomized, placebo‐controlled, crossover trial

European Journal of Heart Failure, EarlyView.
Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is a major healthcare burden with limited treatment options. Geranylgeranylacetone (GGA) has been shown to improve myocardial compliance and endothelial function in preclinical models.
Soufiane Nassiri, Geert H.D. Voordes, Loek van Heerebeek, Daniël H. van Raalte, Marianne C. Verhaar, Daan J. Touw, Merle M. Krebber, Dirk J. Duncker, Etto C. Eringa, M. Louis Handoko, Adriaan A. Voors, on behalf of the RECONNEXT Consortium   +11 more
wiley   +1 more source

Neurotransmitter-gated ion channels at fast chemical synapses: from structure to pathology [PDF]

, 2005
Fil: Bouzat, Cecilia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Investigaciones Bioquímicas de Bahía Blanca. Universidad Nacional del Sur.
Bouzat, Cecilia Beatriz
core  

Retinal waves in mice lacking the β2 subunit of the nicotinic acetylcholine receptor

, 2008
Chao Sun, David K. Warland, José Manuel Bértolo Ballesteros, Deborah van der List, Leo M. Chalupa   +4 more
openalex   +1 more source

Simultaneous Determination of Choline and Acetylcholine Based on a Trienzyme Chemiluminometric Biosensor in a Single Line Flow Injection System [PDF]

, 2003
Nobutoshi Kiba, Seiji Ito, Masaki Tachibana, Kazue Tani, Hitoshi Koizumi   +4 more
openalex   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Acetylcholine-Induced Coronary Vasoconstriction and Negative Inotropy in the Neonatal Pig Heart [PDF]

, 1992
R.J. Ascuitto, Nancy Ross‐Ascuitto, David Ramage, Kathleen H. McDonough, Philip J. Kadowitz   +4 more
openalex   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Experimental autoimmune myasthenia gravis in B10.BV8S2 transgenic mice: preferential usage of TCRAV1 gene by lymphocytes responding to acetylcholine receptor. [PDF]

, 1997
Rashmi Kaul, Bin Wu, E Goluszko, C Deng, Vinesh Dedhia, Gerald Nabozny, C S David, Ilonna J. Rimm, Suchitra Shenoy, Tariq M. Haqqi, Premkumar Christadoss   +10 more
openalex   +1 more source

Neurodevelopmental features in KCNQ2 developmental and epileptic encephalopathy may have limited associations with KV7.2 dysfunction

Epilepsia Open, EarlyView.
Abstract Objective Variants in KCNQ2 encoding the voltage‐gated potassium channel KV7.2 are associated with developmental and epileptic encephalopathy (DEE) of varying severity. This study examined the relationship of KCNQ2 variant dysfunction with the neurodevelopmental phenotype of individuals with KCNQ2‐DEE. Methods A parent‐reported survey gathered
Jessa S. Bidwell, Carlos G. Vanoye, Reshma R. Desai, Anne T. Berg, Alfred L. George Jr   +4 more
wiley   +1 more source

α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

, 2011
Yann S. Mineur, Emily B. Einstein, Patricia A. Seymour, Jotham W. Coe, Brian T. O’Neill, Hans Rollema, Marina R. Picciotto   +6 more
openalex   +2 more sources