Results 121 to 130 of about 217,964 (360)

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Tasha K. Phillips, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +16 more
wiley   +1 more source

Acetylcholine Attenuates Hydrogen Peroxide-Induced Intracellular Calcium Dyshomeostasis Through Both Muscarinic and Nicotinic Receptors in Cardiomyocytes

Cellular Physiology and Biochemistry, 2016
Background/Aims: Oxidative stress induced intracellular Ca2+ overload plays an important role in the pathophysiology of several heart diseases. Acetylcholine (ACh) has been shown to suppress reactive oxygen species generation during oxidative stress ...
Siripong Palee, Nattayaporn Apaijai, Krekwit Shinlapawittayatorn, Siriporn C. Chattipakorn, Nipon Chattipakorn   +4 more
doaj   +1 more source

The molecular cloning and characterisation of cDNA coding for the alpha subunit of the acetylcholine receptor [PDF]

, 1982
The published version of this article is available at Oxford Journals in Nucleic Acids Research at http://nar.oxfordjournals.org/content/10/19/5809.full.pdf+htmlA rare cDNA coding for most of the α subunit of the Torpedo nicotinic acetylcholine receptor ...
Barnard, EA, Bell, L, Houghton, M, Richards, BM, Smith, JC, Sumikawa, K   +5 more
core   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Muscarinic receptor signaling in the pathophysiology of asthma and COPD

Respiratory Research, 2006
Anticholinergics are widely used for the treatment of COPD, and to a lesser extent for asthma. Primarily used as bronchodilators, they reverse the action of vagally derived acetylcholine on airway smooth muscle contraction.
Zaagsma Johan, Gosens Reinoud, Meurs Herman, Halayko Andrew J   +3 more
doaj   +1 more source

Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations [PDF]

, 1992
We measured the permeability ratios (PX/PNa) of 3 wild-type, 1 hybrid, 2 subunit-deficient, and 22 mutant nicotinic receptors expressed in Xenopus oocytes for alkali metal and organic cations using shifts in the bi-ionic reversal potential of the ...
Cohen, Bruce N., Davidson, Norman, Labarca, Cesar, Lester, Henry A.   +3 more
core  

Elevated Hippocampal Cholinergic Neurostimulating Peptide precursor protein (HCNP-pp) mRNA in the amygdala in major depression [PDF]

, 2015
The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD.
Argibay, Pablo, Bassi, Sabrina Cecilia, Seney, Marianne L., Sibille, Etienne   +3 more
core   +1 more source

Fusion Pores as Regulators of Quantal Size and Cellular Physiology

BioEssays, EarlyView.
During regulated exocytosis, membrane fusion regulatory factors act directly on SNAREs and membrane lipids to control fusion pore dynamics. This, in turn, leads to a differential amount of cargo release (referred to in this article as “quantal size”) across various cell types, thereby triggering distinct physiological cues.
Bhavya R. Bhaskar, Shahina Mazumdar, Sruthilaya Dayanandan, Debasis Das   +3 more
wiley   +1 more source

Severe drug-induced repetitive behaviors and striatal overexpression of VAChT in ChAT-ChR2-EYFP BAC transgenic mice

Frontiers in Neural Circuits, 2014
In drug users, drug-related cues alone can induce dopamine release in the dorsal striatum. Instructive cues activate inputs to the striatum from both dopaminergic and cholinergic neurons, which are thought to work together to support motor learning and ...
Jill R Crittenden, Carolyn J Lacey, Tyrone eLee, Hilary A Bowden, Ann M Graybiel   +4 more
doaj   +1 more source

Chemical Characterization, Antioxidant, and Anticholinesterase Activities of Libidibia ferrea (Mart. Ex Tul.) L.P.Queiroz and In Silico Studies with the Acetylcholinesterase Enzyme

Chemistry &Biodiversity, EarlyView.
ABSTRACT Libidibia ferrea is used in many parts of Brazil for a variety of conditions, such as inflammation, respiratory disorders, muscle pain, and gastrointestinal problems. This study evaluated the chemistry and antioxidant and acetylcholinesterase (AChE) inhibitory activities of L. ferrea extracts. Hydroethanolic extracts of leaves (ELLF) and bark (
Lucas Soares Frota, Sara Ingrid Caetano Gomes Barbosa, Camila Costa Feitosa, Francisco Flávio da Silva Lopes, Daniel Pereira de Oliveira, Leonardo Soares Freitas, Adriano Lincoln Albuquerque Mattos, Wildson Max Barbosa da Silva, Hamilton Mitsugu Ishiki, Selene Maia de Morais   +9 more
wiley   +1 more source