Results 141 to 150 of about 217,964 (360)
Similarity of effects of oxygen, sulfur, and selenium isologs on the acetylcholine receptor in excitable membranes of junctions and axons. [PDF]
, 1966 P. Rosenberg +2 more
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ChemMedChem, EarlyView.Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti +4 more
wiley +1 more source
Clinical Pharmacology in Drug Development, EarlyView.Abstract TAK‐071 is a novel muscarinic M1 positive allosteric modulator under investigation for the treatment of cognitive impairment and falls associated with Parkinson disease (PD). This study evaluated population pharmacokinetics of TAK‐071 following single (1‐160 mg) and multiple (3‐15 mg once daily) oral‐dose TAK‐071 in 112 healthy participants ...
Hongxia Jia +8 more
wiley +1 more source
Erratum to: Effect of Acetylcholine on the Cardiovascular and Respiratory System in Different Experimental Preparations (and the Role of Baro-Receptors) [PDF]
, 1960 S. R. Mukherjee, J. Mitra, B. N. Koley
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Clinical Pharmacology in Drug Development, EarlyView.Abstract BNC210 is an investigational small molecule selective negative allosteric modulator of the alpha‐7 nicotinic acetylcholine receptor (α7 nAChR). It is an anxiolytic compound with a novel mechanism of action. In a series of Phase 1 clinical trials in healthy volunteers, psychometric test batteries showed that BNC210 did not cause attention ...
Paul Rolan +7 more
wiley +1 more source
Acetylcholine Receptors of Insects
, 1980 Publisher Summary Insects have provided material well suited to the investigation of CNS acetylcholine receptors. The central nervous tissues of these organisms have proved amenable to both radiolabelled- ligand-binding studies and single-cell electrophysiology of identifiable neurones. Binding studies have resulted in the characterization in vitro
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International Journal of Eating Disorders, EarlyView.ABSTRACT Objective Converging evidence from neuroimaging studies and genome‐wide association study (GWAS) suggests the involvement of prefrontal cortex (PFC) and striatum dysfunction in the pathophysiology of anorexia nervosa (AN). However, identifying the causal role of circuit‐specific genes in the development of the AN‐like phenotype remains ...
K. Huang +7 more
wiley +1 more source
Early events in neuromuscular junction formation in vitro: induction of acetylcholine receptor clusters in the postsynaptic membrane and morphology of newly formed synapses. [PDF]
, 1979 E Frank, G D Fischbach
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Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction
ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu +3 more
wiley +1 more source
Prenatal Nicotine Exposure as a Teratogen in Neurological Pathways [PDF]
, 2016 Attention-deficit/hyperactivity disorder (ADHD) is the most heritable and commonly diagnosed childhood psychiatric disorder with 4% of all children being diagnosed with this disorder.
Grover, Monica
core +1 more source