Results 161 to 170 of about 128,683 (214)

The Pathway to Proof-of-Concept for BNC210, a Negative Allosteric Modulator of the Alpha-7 Nicotinic Acetylcholine Receptor (nAChR), for Treatment of Psychiatric Disease. [PDF]

Clin Pharmacol Drug Dev
Rolan P, Doolin E, Paul D, Crossman J, Odontiadis M, Danjou P, Smith M, Papapetropoulos S.   +7 more
europepmc   +1 more source

Computational model of alpha 7 nicotinic acetylcholine receptor in thalamic reticular nucleus neurons and their involvement in network states. [PDF]

PLoS One
Ullah A, Therrien K, Cressman JR, Kabbani N.   +3 more
europepmc   +1 more source

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition. [PDF]

Nat Commun
Su J, Yu Z, Yin Z, Zhang Z, Zhao J, Meng Y, Li R, Gao Y, Zhang H, Yu R, Zhao Y.   +10 more
europepmc   +1 more source

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Acetylcholine receptor kinetics

Journal of Membrane Biology, 1981
P R Adams, Adams P R
exaly   +3 more sources

Acetylcholine receptors

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1975
Abstract a-Bungarotoxin is one of a class of proteins, isolated from snake venoms, which antagonize the action of acetylcholine at vertebrate neuromuscular junctions and ‘electroplaques' of electric fish. a-Bungarotoxin blocks acetylcholine action irreversibly and may be labelled with either 125I or 3H.
D P, Green, R, Miledi, M, Perez de la Mora, A, Vincent   +3 more
openaire   +2 more sources

Muscarinic Acetylcholine Receptors

Current Pharmaceutical Design, 2006
Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru, Ishii, Yoshihisa, Kurachi
openaire   +2 more sources

The biochemistry of an acetylcholine receptor

Journal of Supramolecular Structure, 1974
AbstractThe acetylcholine receptor from Torpedo californica electroplax has been studied at three levels of molecular organization: receptor‐rich membrane fragments, solubilized and purified receptor, and reconstituted receptor in phospholipid vesicles.
M A, Raftery, R, Vandlen, D, Michaelson, J, Bode, T, Moody, Y, Chao, K, Reed, J, Deutsch, J, Duguid   +8 more
openaire   +2 more sources

Muscarinic acetylcholine receptor

Progress in Neurobiology, 1978
ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
E, Heilbronn, T, Bartfai
openaire   +2 more sources

Isolation of Acetylcholine Receptors

Annual Review of Pharmacology, 1972
When ACh acts in an excitatory way, it increases the conductance of a post-synaptic membrane for Na+ and K+, leading to membrane depolariza­ tion. We shall use the term acetylcholine receptor (AChR) for those ma­ cromolecules involved in this transduction that bear the recognition site( s) for ACh and other cholinergic ligands.
R D, O'Brien, M E, Eldefrawi, A T, Eldefrawi   +2 more
openaire   +2 more sources