Results 171 to 180 of about 128,683 (214)

The acetylcholine receptor

Trends in Pharmacological Sciences, 1979
Neurons communicate with their target cells mostly by chemical means. The molecules involved, neurotransmitters. are in general small molecules which are liberated by nerve terminals upon rapid variation of the membrane potential. The ch.ange of neurotransmitter concentration in the synapse with time constitutes the ‘signal’ for inter-cellular ...
Jérôme Giraudat, Jean-Pierre Changeux
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Phosphorylation of the Acetylcholine Receptor

1979
There is increasing evidence that disorders of recep tor function account for several major clinical diseases. In the nervous system, two of the most striking examples are myasthenia gravis and tardive dyskinesia. Each of these conditions is associated with a change in the number and/or sensitivity of a neurotransmitter receptor.
A S, Gordon, I, Diamond
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Immunology of the Acetylcholine Receptor

Immunological Communications, 1976
Myasthenia gravis is a spontaneously occurring autoimmune disease in which antibodies and lymphocytes are specifically reactive with nicotinic ACh receptors of skeletal muscle. Antibodies reactive with junctional receptors of human muscle are found in 90% of patients with myasthenia gravis and not at all in other diseases.
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Acetylcholine receptors and myasthenia

Muscle & Nerve, 2000
Much progress has been made in the 26 years since initial studies of the first purified acetylcholine receptors (AChRs) led to the discovery that an antibody-mediated autoimmune response to AChRs causes the muscular weakness and fatigability characteristic of myasthenia gravis (MG) and its animal model, experimental autoimmune myasthenia gravis (EAMG).
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Is the Acetylcholine Receptor a Rabies Virus Receptor?

Science, 1982
Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with α-bungarotoxin and d -tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus ...
T L, Lentz, T G, Burrage, A L, Smith, J, Crick, G H, Tignor   +4 more
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Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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The acetylcholine receptor: Progress report

Life Sciences, 1974
Publisher Summary This chapter presents a progress report on the acetylcholine receptor (ACHR). All approaches to the ACHR begin with the response of cells to ACH and the modification of this response. The binding properties of the ACHR are inferred from the variation of the response as a function of the concentration of ACH and of its congeners.
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Autoimmune Response to Acetylcholine Receptor

Science, 1973
Injection of rabbits with acetylcholine receptor highly purified from the electric organ of Electrophorus electricus emulsified in complete Freund's adjuvant resulted in the production of precipitating antibody to acetylcholine receptor.
J, Patrick, J, Lindstrom
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Acetylcholinesterase and Acetylcholine Receptor.

1985
Abstract : Our study of acetylcholinesterase (AcChE) is based on the view that the Beta-trimethylammonio substituent of acetylcholine binds at an uncharged subsite, better termed 'trimethyl' than 'anionic,' and would be more specifically explored by uncharged reagents.
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Nicotinic Acetylcholine Receptors and Epilepsy

Current Drug Target -CNS & Neurological Disorders, 2002
The neuronal nicotinic acetylcholine receptors (nAChRs) have multiple roles in the brain: they are involved in signal transduction by fast synaptic transmission, axo-axonic transmission, and in the modulation of presynaptic transmitter release. Presynaptic nAChRs can increase the release of excitatory as well as of inhibitory transmitters, and can ...
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