Results 201 to 210 of about 217,964 (360)

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

Medicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg, Tracie Widjaja, Adriaan P. IJzerman, Daan van der Es   +3 more
wiley   +1 more source

Retraction: Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling. [PDF]

J Biol Chem
Hirota K, Fukuda R, Takabuchi S, Kizaka-Kondoh S, Adachi T, Fukuda K, Semenza GL.   +6 more
europepmc   +1 more source

Increased Nitrate Intake From Beetroot Juice Over 4 Weeks Changes the Composition of the Oral, But Not the Intestinal Microbiome

Molecular Nutrition &Food Research, EarlyView.
This randomized, double‐blind, and placebo‐controlled crossover study investigated the effects of an increased intake of inorganic nitrate from beetroot juice over 4 weeks on the oral and intestinal microbial communities in older adults with treated high blood pressure.
Rebeka Fejes, Joana Séneca, Petra Pjevac, Martin Lutnik, Stefan Weisshaar, Nina Pilat, Romy Steiner, Karl‐Heinz Wagner, Richard J. Woodman, Catherine P. Bondonno, Jonathan M. Hodgson, David Berry, Michael Wolzt, Oliver Neubauer   +13 more
wiley   +1 more source

Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole‐Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy

ChemistryOpen, EarlyView.
GA: Oxidative stress plays a critical role in Alzheimer's disease (AD) by promoting Aβ plaque accumulation and tau pathology, accelerating neurodegeneration. Elevated reactive oxygen species contribute to cognitive decline through extensive oxidative damage.
Abdüllatif Karakaya, Ulviye Acar Çevik, Betül Kaya, Bilge Çiftçi, Adem Necip, Mesut Işık, Şükrü Beydemir, Yusuf Özkay, Zafer Asım Kaplancıklı   +8 more
wiley   +1 more source

Perspectives on the α5 nicotinic acetylcholine receptor in lung cancer progression. [PDF]

Front Cell Dev Biol
Cai J, Wang J, Wang Z, Wang J, Jia Y, Ma X.   +5 more
europepmc   +1 more source

An analysis of acetylcholine responses of junctional and extrajunctional receptors of frog muscle fibres. With an Appendix

, 1971
Anne Feltz, A Mallart, Richard Kahn, A. le Yaouanc   +3 more
openalex   +1 more source

Comparison between the affinities for reversible cholinergic ligands of a purified and membrane bound state of the acetylcholine‐receptor protein from Electrophorus electricus [PDF]

, 1973
Jean‐Claude Meunier, Jean‐Pierre Changeux   +1 more
openalex   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Effects of Selective α7 Nicotinic Acetylcholine Receptor Stimulation in Oligodendrocytes: Putative Implication in Neuroinflammation. [PDF]

Cells
Guerriero C, Puliatti G, Di Marino T, Scanavino G, Matera C, Dallanoce C, Tata AM.   +6 more
europepmc   +1 more source

Localization of acetylcholine receptor in excitable membrane from the electric organ of Torpedo: Evidence for exposure of receptor antigenic sites on both sides of the membrane. [PDF]

, 1978
R Tarrab-Hazdai, Benjamin Geiger, Sara Fuchs, Abraham Amsterdam   +3 more
openalex   +1 more source