Results 201 to 210 of about 116,451 (242)

Phosphorylation of the Acetylcholine Receptor

1979
There is increasing evidence that disorders of recep tor function account for several major clinical diseases. In the nervous system, two of the most striking examples are myasthenia gravis and tardive dyskinesia. Each of these conditions is associated with a change in the number and/or sensitivity of a neurotransmitter receptor.
Ivan Diamond, Adrienne S. Gordon
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Nicotinic Acetylcholine Receptors

2003
Publisher Summary This chapter deals with nicotinic acetylcholine receptors. Nicotinic acetylcholine receptors (nAChRs) are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction. As ionotropic receptors, nAChRs are directly linked to ion channels
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Immunology of the Acetylcholine Receptor

Immunological Communications, 1976
Myasthenia gravis is a spontaneously occurring autoimmune disease in which antibodies and lymphocytes are specifically reactive with nicotinic ACh receptors of skeletal muscle. Antibodies reactive with junctional receptors of human muscle are found in 90% of patients with myasthenia gravis and not at all in other diseases.
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Acetylcholine receptors and myasthenia

Muscle & Nerve, 2000
Much progress has been made in the 26 years since initial studies of the first purified acetylcholine receptors (AChRs) led to the discovery that an antibody-mediated autoimmune response to AChRs causes the muscular weakness and fatigability characteristic of myasthenia gravis (MG) and its animal model, experimental autoimmune myasthenia gravis (EAMG).
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Acetylcholine Receptor Structure

2003
Over the past decade, studies of the atomic structure and the structural mechanism of nicotinic acetylcholine receptor (AChR) gating have reached an advanced stage. AChRs are members and prototypes of the superfamily of Cys-loop pentameric ligand-gated ion channels.
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Acetylcholinesterase and Acetylcholine Receptor. [PDF]

, 1985
Abstract : Our study of acetylcholinesterase (AcChE) is based on the view that the Beta-trimethylammonio substituent of acetylcholine binds at an uncharged subsite, better termed 'trimethyl' than 'anionic,' and would be more specifically explored by uncharged reagents.
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Is the Acetylcholine Receptor a Rabies Virus Receptor?

Science, 1982
Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with α-bungarotoxin and d -tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus ...
Abigail L. Smith, Thomas L. Lentz, Gregory H. Tignor, Joan Crick, Thomas G. Burrage   +4 more
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Acetylcholine and Its Receptors

1997
This chapter explores the role of acetylcholine (ACh) and its receptors in neurogenic control of brain microvascular functions. Experimental results suggest that cerebral blood flow (CBF) increases considerably in the ipsilateral frontal and parietal cortices in response to electrical stimulation of the substantia innominata in rats.
Donald G. Linville, Edith Hamel
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The acetylcholine receptor: Progress report

Life Sciences, 1974
Publisher Summary This chapter presents a progress report on the acetylcholine receptor (ACHR). All approaches to the ACHR begin with the response of cells to ACH and the modification of this response. The binding properties of the ACHR are inferred from the variation of the response as a function of the concentration of ACH and of its congeners.
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Muscarinic Acetylcholine Receptors

2004
Muscarinic acetylcholine receptors are members of the G-protein-coupled receptor superfamily. There are five genes encoding the muscarinic receptors, which are expressed to different extents in a variety of tissues, including cardiac and smooth muscle, secretory glands, and neurons and glial cells in the central and peripheral nervous systems ...
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