Results 301 to 310 of about 176,114 (393)

Protein aggregation and neurodegenerative disease: Structural outlook for the novel therapeutics

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 8, Page 1314-1329, August 2025.
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to the soluble amyloid‐β protofibrils, all the treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling to find a breakthrough in AD therapeutic medicine, which is partially attributable to lack in ...
Sharif Arar, Md Anzarul Haque, Rakez Kayed   +2 more
wiley   +1 more source

Multi‐Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
ABSTRACT Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid‐beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single‐target drugs has been
Md Saad Hossain, Md Hamed Hussain
wiley   +1 more source

The inhibitory activities of two compounds from Securidaca longepedunculata Fresen on the acetylcholinesterase from wheat pest Schizaphis graminum Rondani: in silico analysis. [PDF]

Plant Signal Behav
Guiré R, Salo P, Zongo E, Ramadan MF, Koama BK, Meda RN, Al-Asmari F, Rahim MA.   +7 more
europepmc   +1 more source

Anatomy and projection patterns of the superior olivary complex in the mexican free-tailed bat, Tadarida brasiliensis mexicana [PDF]

, 1994
Grothe, Benedikt, Pollak, George D., Rosemann, Christina, Schuller, Gerd, Schweizer, Hermann   +4 more
core   +1 more source

Sulphonylureas as Adjunct Therapeutic Agents in the Treatment of Autoimmune Conditions: A Narrative Review

Pharmacology Research &Perspectives, Volume 13, Issue 4, August 2025.
NLRP3 Inflammasome activation drives inflammatory responses through the production and activation of pro‐inflammatory cytokines. Repurposing sulphonylureas and their derivatives to target NLRP3 may act as adjunct therapeutics for autoimmune conditions. ABSTRACT A rapid and cost‐effective arm of the drug discovery and development process is finding new ...
Jasen Elford, Robert J. O'Reilly, Anna‐Marie Babey, Rukshan Ahamed Mohamed Rafeek, Natkunam Ketheesan   +4 more
wiley   +1 more source

Salt Stress Enhanced Bioactivity of Quinoa Leaf Extracts: An In Vitro and In Silico Study of Acetylcholinesterase and Tyrosinase Inhibition for Sustainable Drug Development. [PDF]

Pharmaceuticals (Basel)
Slimani N, Arraouadi S, Hajlaoui H, Cid-Samamed A, Borgi MA, Snoussi M.   +5 more
europepmc   +1 more source

Modeling, virtual screening, and enzymatic docking of trehalose 6‐phosphate phosphatase and evaluation of the insecticidal effect of phthalimide, N‐(p‐tolylsulfonyl) on Aedes aegypti (Diptera: Culicidae)

Pest Management Science, Volume 81, Issue 8, Page 4777-4787, August 2025.
Schematic diagram of the experimental procedures used to perform the bioinformatic steps and insecticidal assays using trehalose 6‐phosphate phosphatase of Aedes aegypti and the molecule phthalimide, N‐(p‐tolylsulfonyl). Abstract BACKGROUND Aedes aegypti Linnaeus is a medically important vector because of its role in transmitting several arboviruses ...
Raquel Jemima Viana Lima, Fernando Berton Zanchi, Railton Marques de Souza Guimarães, Alexandre de Almeida e Silva   +3 more
wiley   +1 more source

Bifenthrin resistance in Dalbulus maidis (Hemiptera: Cicadellidae): inheritance, cross‐resistance, and stability

Pest Management Science, Volume 81, Issue 8, Page 4810-4820, August 2025.
Resistance of Dalbulus maidis to bifenthrin was autosomal, incompletely dominant, and polygenic. Additionally, this resistance was unstable in the absence of selection pressure. Abstract BACKGROUND Pyrethroid insecticides have been a primary strategy for managing Dalbulus maidis (Hemiptera: Cicadellidae) in Brazil. Howeve, failures in the control of D.
Gabriel Silva Dias, Eduardo Perkovski Machado, Matheus Gerage Sacilotto, Leonardo Vinicius Thiesen, Celso Omoto   +4 more
wiley   +1 more source

Differential senolytic inhibition of normal versus Aβ-associated cholinesterases: implications in aging and Alzheimer's disease. [PDF]

Aging (Albany NY)
Darvesh S, Cash MK, Forrestall K, Maillet H, Sands D.   +4 more
europepmc   +1 more source