Results 311 to 320 of about 125,133 (347)

Isoenzymes of elapid acetylcholinesterases

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1977
Abstract 1. Acetylcholinesterase activity of Naja naja naja, Naja melanoleuca and Bungarus fasciatus venoms is due to mixtures of isoenzymes. 2. Naja melanoleuca venom has two acetylcholinesterase isozymes and both Naja naja naja and Bungarus fasciatus venoms have four acetylcholinesterase isozymes that are resolved by disc gel ...
W.B. Elliott, Jenefer Liu Latta, Su-Ray Lee   +2 more
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Inhibition of acetylcholinesterase by anisomycin

Life Sciences, 1976
Abstract The antibiotic anisomycin, an inhibitor of protein synthesis in eucaryotic cells, which blocks long-term memory in mice, is shown to interact with the cholinergic system by inhibiting reversibly the acetylcholinesterase. The inhibition is a competitive one, the inhibition constant K i being 5.0 × 10 −3 for human brain acetylcholinesterase ...
Götz F. Domagk, Ronald Zech
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The interaction of carbamates with acetylcholinesterase

Biochemical Pharmacology, 1977
Abstract It has been shown that the kinetic schemes proposed by earlier workers to describe the reactions of carbamates with acetylcholinesterase are incomplete. A reaction scheme has been developed and tested by the use of methyl- and dimethyl-carbamoylcholines; it adequately explains the reactions observed in the carbamate-enzyme system, including ...
P. Watts, Rodney G. Wilkinson
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Acetylcholinesterase

1987
International ...
Toutant, J.P., Massoulie, J.
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Subunit heterogeneity of acetylcholinesterase

Archives of Biochemistry and Biophysics, 1974
Abstract Several different preparations of purified 11 S acetylcholinesterase have been examined for structural heterogeneity. While no contaminant protein was observed in any of the preparations, minor isozymic forms with catalytic activity were observed in addition to the major component both in polyacrylamide gel electrophoresis and in isoelectric
Yueh T. Chen, Terrone L. Rosenberry, Hai Won Chang   +2 more
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Computer Modeling of Acetylcholinesterase and Acetylcholinesterase-Ligand Complexes

1995
Site directed mutagenesis and computer simulations studies have become valuable tools for the understanding of function-structure relations of proteins. At the current level of computer technology, the quantitative agreement between experimental and molecular simulations results is not always satisfactory for proteins of acetylcholinesterase (AChE ...
James Andrew McCammon, J. Antosiewicz, J. Antosiewicz, L.R. Scott, Terry W. Clark, Stanislaw T. Wlodek, Michael K. Gilson   +6 more
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On the homogeneity of 11-S acetylcholinesterase

Biochimica et Biophysica Acta (BBA) - Enzymology, 1978
11-S acetylcholinesterase (acetylcholine hydrolase, EC 3.1.1.7) purified by affinity chromatography of trypsin-digested homogenates was shown to be contaminated with three other active forms of enzyme. The initial purification used an affinity column of the inhibitor, N-methylacridinium ion.
John P. Christopher, David B. Millar, Colin F. Chignell, Leon Kurlansik   +3 more
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Ibogaine and the inhibition of acetylcholinesterase

Journal of Ethnopharmacology, 2012
Ibogaine is a psychoactive monoterpine indole alkaloid extracted from the root bark of Tabernanthe iboga Baill. that is used globally in medical and nonmedical settings to treat drug and alcohol addiction, and is of interest as an ethnopharmacological prototype for experimental investigation and pharmaceutical development.
Maarten E. A. Reith, Kenneth Alper, Henry Sershen, Henry Sershen   +3 more
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Plasma acetylcholinesterase activity

American Journal of Obstetrics and Gynecology, 1950
Abstract ChE activity in plasma from normal adult nonmenstruating, nonpregnant women, from women during normal pregnancy, and from patients with toxemia of pregnancy was determined manometrically. Significant differences were observed among the three groups. This difference was independent of medication (Sodium Amytal), and could not be attributed to
W.W. Tourtellotte, Lester D. Odell
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Autoantibodies to acetylcholinesterase revisited

Journal of the Neurological Sciences, 2000
A sensitive and specific enzyme linked immunosorbent assay (ELISA) utilizing human recombinant acetylcholinesterase has been employed for the detection of human antibodies to human acetylcholinesterase. The method can detect allogenic antibodies to the Yt(a) form of human erythrocyte AChE. Adaptation of this ELISA method allowed the IgG subclass typing
A Strachan, S Hadjikoutis, S.I. Hogg, C.M Wiles, J Geen, D.A. Hullin   +5 more
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