Results 321 to 330 of about 176,114 (393)
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Acta Physiologica, 2020
Cardiovascular diseases remain a major cause of morbidity and mortality worldwide. Cardiovascular diseases such as acute myocardial infarction, ischaemia/reperfusion injury and heart failure are associated with cardiac autonomic imbalance characterized ...
Siriporn C Chattipakorn +1 more
exaly +2 more sources
Cardiovascular diseases remain a major cause of morbidity and mortality worldwide. Cardiovascular diseases such as acute myocardial infarction, ischaemia/reperfusion injury and heart failure are associated with cardiac autonomic imbalance characterized ...
Siriporn C Chattipakorn +1 more
exaly +2 more sources
Acetylcholinesterase — new roles for an old actor
Nature Reviews Neuroscience, 2001Hermona Soreq
exaly +2 more sources
Discovery of sulfadrug–pyrrole conjugates as carbonic anhydrase and acetylcholinesterase inhibitors
Archiv der Pharmazie, 2021Human carbonic anhydrase (hCA) isoenzymes are zinc ion‐containing, widespread metalloenzymes and they classically play a role in pH homeostasis maintenance.
M. Gümüş +5 more
semanticscholar +1 more source
Potent Acetylcholinesterase Inhibitors: Potential Drugs for Alzheimer's Disease.
Mini-Reviews in Medical Chemistry, 2020Alzheimer's disease (AD) is one of the cognitive or memory related impairment occurring with advancing age. Since its exact mechanism is not known, the full therapy has not still been found.
Hulya Akıncıoğlu, I. Gülçin
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Angewandte Chemie International Edition in English, 1967
AbstractAcetylcholinesterase plays a vital part in the functioning of nerves, and serious physiological damage arises from its blockage by esters of phosphonic and phosphoric acid used e. g. in pesticides. The properties and the mechanism of action of acetylcholinesterase, which show many similarities to those of other hydrolases, are described ...
N, Engelhard, K, Prchal, M, Nenner
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AbstractAcetylcholinesterase plays a vital part in the functioning of nerves, and serious physiological damage arises from its blockage by esters of phosphonic and phosphoric acid used e. g. in pesticides. The properties and the mechanism of action of acetylcholinesterase, which show many similarities to those of other hydrolases, are described ...
N, Engelhard, K, Prchal, M, Nenner
openaire +2 more sources
Tetrahydrocannabinol and acetylcholinesterase
Pharmacology Biochemistry and Behavior, 1978Recent evidence suggests that the psychoactive effect of delta-9-tetrahydrocannabinol (delta9-THC), the major psychoactive constituent of marihuana, may be mediated through an alteration of cholinergic neurotransmission. One possible mechanism by which delta9-THC could have its effect is by affecting acetylcholinesterase (AChE) and there is evidence ...
Donald E. Moss, R.R. Salome, P.L. Peck
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Biophysics of Structure and Mechanism, 1980
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
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Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
openaire +2 more sources
Target Enzyme in Alzheimer's Disease: Acetylcholinesterase Inhibitors.
Current Topics in Medicinal Chemistry, 2019Alzheimer's Disease (AD), affecting a large population worldwide is characterized by the loss of memory and learning ability in the old population. The enzyme Acetylcholinesterase Enzyme (AChE) is the key enzyme in the hydrolysis of the neurotransmitter ...
M. Saxena, R. Dubey
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A Flexible Acetylcholinesterase-Modified Graphene for Chiral Pesticide Sensor.
Journal of the American Chemical Society, 2019Sensors based on graphene are promising devices for chemical and biological detection owing to their high sensitivity, bio-compatibility, and low costs.
Yunpeng Zhang +9 more
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