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Acetylsalicylic Acid

Der Anaesthesist, 2000
Abstract A Uncouples oxidative phosphorylation Acetylsalicylic acid (aspirin), the synthetic derivative of salicylic acid, is one of the most widely used medications; it is the prototypical nonopioid analgesic, antipyretic, and anti inflammatory agent. Inhibition of the prostaglandin biosynthetic enzyme cyclooxygenase is thought to be
R, Fretschner, K, Unertl
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ACETYLSALICYLIC ACID AND ACETAMINOPHEN

Dental Clinics of North America, 1994
Aspirin is the most extensively prescribed analgesic, antipyretic, and anti-inflammatory agent. It is effective against the mild-to-moderate pain of inflammation. The best single dose of aspirin is that which is adequate to relieve pain; the proper dosage interval is that which sustains relief without causing toxicity.
G, Kacso, G T, Terézhalmy
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Analysis of Acetylsalicylic Acid and Acetylsalicylic Acid Tablets

Journal of Pharmaceutical Sciences, 1961
The U. S. P. assays for acetylsalicylic acid and its tablets are not universally applicable to these dosage forms containing buffers, flavoring agents, coloring materials, and enteric coatings. The U. S. P. test for free salicylic acid is not quantitative and may be subject to error unless additional controls are provided.
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Ototoxicity of Acetylsalicylic Acid

Archives of Otolaryngology - Head and Neck Surgery, 1965
ASPIRIN (acetylsalicylic acid) is generally regarded as one of the safest drugs. It is widely used by the layman and freely prescribed by all physicians. It is thought that about 9 million pounds of aspirin alone are consumed yearly in the United States. 1 As early as 1922, Pohlman and Kranz 2 were experimenting in St.
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ACETYLSALICYLIC ACID POISONING WITH RECOVERY

Archives of Pediatrics & Adolescent Medicine, 1947
ACETYLSALICYLIC acid and the other salicylates are among the least toxic of the commonly used active pharmacopeial preparations. Clinical reports of salicylate intoxication are relatively infrequent, though the quantities of these medicaments consumed throughout the world in the past fifty years have been enormous. The apparently benign status of these
J B, GILLESPIE, R E, KUKES
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The Stability of Acetylsalicylic Acid in Suspension

Journal of the American Pharmaceutical Association (Scientific ed.), 1959
The effect of temperature and concentration on the hydrolysis rate of acetylsalicylic acid suspensions was studied. As would be expected for a zero-order reaction the more concentrated suspensions showed a longer half-life. The effect of additives on the stability of the aqueous suspensions was evaluated.
S M, BLAUG, J W, WESOLOWSKI
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Interaction by bendrofluazide with acetylsalicylic acid

General Pharmacology: The Vascular System, 1986
The effects of aspirin and bendrofluazide alone and in combination were studied on the diuresis, natriuresis, kalliuresis and excretion of salicylates in normal human volunteers. The simultaneous administration of both drugs in a sequence of aspirin-bendrofluazide was accompanied by a reduction in the kalliuretic effect of aspirin without any ...
A O, Oyekan, A A, Laniyonu
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PURPURA AND ACETYLSALICYLIC ACID THERAPY

Acta Paediatrica, 1971
SummaryThree cases are reported of children presenting purpura while taking a normal dose of ace‐tylsalicylic acid since a few days. Studies of the platelet function showed an impaired platelet aggregation by an inhibition of ADP release. It is concluded that this mechanism is responsible for the clinical findings, and that an acetylsalicylic acid ...
M, Casteels-Van Daele, G, De Gaetano
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Acetylsalicylic Acid and HL-A Antigens

Annals of Internal Medicine, 1972
Excerpt To the editor: Butler and Rossen (1) recently reported a major alteration in the detected HL-A antigens of lymphocytes in three of four patients taking therapeutic acetylsalicylic acid.
A S, Russell   +2 more
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Acetylsalicylic acid and autonomic modulation

Clinical Autonomic Research, 2000
Loss of autonomic balance characterized by increased sympathetic activity and decreased vagal activity has been implicated as a major cardiovascular risk factor. Aspirin's cardioprotective abilities involve a multitude of physiologic processes. However, the effects of aspirin on cardiac autonomic activity are unknown. In a double-blind crossover study,
R E, De Meersman   +3 more
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