The analgesic effects of anti-inflammatory drugs from the point of view of different pharmacological test methods [PDF]
1. The forms of irritation causing inflammation and pain are reviewed, with reference to the significance of histamine, serotonin and bradykinin and in particular to the interrelationship between inflammation and pain. 2.
Wilhelmi, G.
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This study evaluates the role of elastin in vascular response 28 days after balloon angioplasty using uncoated and paclitaxel‐coated balloons in a healthy porcine model. The results show higher elastin content in external femoral arteries, which is inversely correlated with vascular injury, inflammation, smooth muscle cell loss, proteoglycan and fibrin
María Gracia de Garnica García+7 more
wiley +1 more source
The effects of carboxylic acids on the aqueous dispersion and electrophoretic deposition of ZrO2 [PDF]
The agglomeration, electrokinetic properties and electrophoretic deposition behaviour of aqueous suspensions of ZrO2 with carboxylic acid additives were studied in comparison with conventional pH adjustment. It was found that citric acid imparted negative zeta-potential values and electrosteric stabilisation to particles in suspensions at all pH levels.
arxiv +1 more source
Ruthenium Catalyzed ortho‐Arylation Reaction of Benzoic Acids with Arylthianthrenium Salts
Arylthianthrenium salts have become key intermediates for late‐stage functionalizations of drug‐like molecules. Ruthenium‐phosphine catalysts are now shown to enable their use as aryl sources in high‐yielding ortho‐C–H arylations of benzoic acids. The arylthianthrenium salts are converted chemo‐selectively, leaving aryl halides and boronates untouched.
Kaiping Wang+9 more
wiley +1 more source
Abstract The development of humanized IgG1 anti‐amyloid monoclonal antibodies, such as lecanemab, provides a promising novel treatment pathway with potential disease‐modifying effects for patients with early Alzheimer's disease (AD). Lecanemab, which gained marketing approval by the United States Food and Drug Administration (US FDA) in July 2023, has ...
Amy Bobbins+5 more
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Nature's Starships. I. Observed Abundances and Relative Frequencies of Amino Acids in Meteorites [PDF]
The class of meteorites called carbonaceous chondrites are examples of material from the solar system which have been relatively unchanged from the time of their initial formation. These meteorites have been classified according to the temperatures and physical conditions of their parent planetesimals.
arxiv +1 more source
Fabrication and Characterization of Electrospun Drug-eluting Nanofibers from Polycaprolactone/Chitosan Blends [PDF]
Electrospinning has emerged as a widely accepted technique with ability to produce nanofibers that can be employed in many biomedical applications. In particular, drug-eluting nanofibers have become very popular in controlled release of small molecule ...
Chou, Shih-Feng+2 more
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Pharmacology and relevant drug interactions of metamizole
Metamizole is a frequently prescribed analgesic because of its favourable benefit/risk ratio compared with classic NSAIDs. However, increasing research shows that metamizole displays several drug interactions that are relevant to clinical practice. We reviewed the literature to summarize the pharmacology and most clinically relevant drug interactions ...
David J. Brinkman+3 more
wiley +1 more source
Meteoritic Abundances of Fatty Acids and Potential Reaction Pathways in Planetesimals [PDF]
The origin of fatty acids on the prebiotic Earth is important as they likely formed the encapsulating membranes of the first protocells. Carbon-rich meteorites (i.e., carbonaceous chondrites) such as Murchison and Tagish Lake are well known to contain these molecules, and their delivery to the early planet by intense early meteorite bombardments ...
arxiv +1 more source
Multi-Behavioral Endpoint Testing Of An 87-Chemical Compound Library In Freshwater Planarians [PDF]
There is an increased recognition in the field of toxicology of the value of medium-to-high-throughput screening methods using in vitro and alternative animal models.
Collins, Eva-Maria S.+4 more
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