Results 151 to 160 of about 91,412 (386)
Cancer Communications, EarlyView.Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu +12 more
wiley +1 more source
Effect of Undercutting on the Acetylcholinesterase and Choline Acetyltransferase Activity in the Cat's Cerebral Cortex [PDF]
, 1963 Catherine O. Hebb +2 more
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Chemistry &Biodiversity, EarlyView.Combining bacterially inactivated antibiotics with antibacterial essential oils (EOs) is an alternative combinatorial therapy against antibiotic‐resistant bacteria, as EOs can also modulate resistance. Apart from the rehabilitation of the antibiotic, this combination is probably more difficult to overcome evolutionarily due to the antibacterial mixture
Rafael Torres‐Martínez +5 more
wiley +1 more source
Nature Communications, 2019 E2F1, which localises to DNA double-strand breaks (DSBs) to promote repair, is acetylated in response to DNA damage but the role this plays in DNA repair is unknown. Here the authors show that E2F1 acetylation creates a binding motif for the bromodomains
Swarnalatha Manickavinayaham +8 more
doaj +1 more source
A tailored phospho‐p53 library probes antibody specificity and recognition limitations
ChemBioChem, Accepted Article.The tumour suppressor protein p53, known as the "guardian of the genome", is regulated by a complex network of posttranslational modifications (PTMs). Phosphorylations at 7 Ser/Thr residues within the N‐terminal transactivation domain 1 (TAD1) play a role in p53 activation, yet their precise mechanisms of action remain elusive due to challenges in ...
Mateusz Hess +6 more
wiley +1 more source
Journal of Biological Chemistry, 1974 Abstract Choline acetyltransferase (EC 2.3.1.6) catalyzes the reversible transfer of the acetyl group from acetyl coenzyme A to choline. Previous studies are consistent with the idea that an active site sulfhydryl group reacts with acetyl coenzyme A to form an acetyl-thioenzyme intermediate and coenzyme A (Roskoski, R., Jr. (1973) Biochemistry 12, 3709)
openaire +3 more sources
Temperature-sensitive Chloramphenicol Acetyltransferase from Escherichia coli Carrying Mutant R Factors [PDF]
, 1968 Katsutoshi Mise, Yoshiaki Suzuki
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Acetylation‐Deacetylation‐Driven Natural Product Biosynthesis
ChemistryEurope, EarlyView.This review summarizes the role of acetylation‐deacetylation in natural product biosynthesis, including acetylation followed by deacetylation after several biosynthetic steps, acetylation‐mediated rearrangement, acetylation‐triggered elimination, and the acetylation cycle as a regulatory mechanism. These processes are vital for the formation of complex
Huibin Wang, Ikuro Abe
wiley +1 more source
Dynamics-function relationship in the catalytic domains of N-terminal acetyltransferases
Computational and Structural Biotechnology Journal, 2020 N-terminal acetyltransferases (NATs) belong to the superfamily of acetyltransferases. They are enzymes catalysing the transfer of an acetyl group from acetyl coenzyme A to the N-terminus of polypeptide chains.
Angèle Abboud +4 more
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