Integrative analysis of CUT&Tag-seq and RNA-seq reveals widespread H3K27ac upregulation associated with the activation of muscle-growth-related transcriptional programs in broiler breast muscle. [PDF]
Cai G +12 more
europepmc +1 more source
The epigenetic landscape of skeletal muscle in response to exercise and aging
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley +1 more source
5-Thiohistidine N-Acetyltransferase from Proteiniphilum Saccharofermentans. [PDF]
Liao C +3 more
europepmc +1 more source
Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture +3 more
wiley +1 more source
Crosstalk between acetylation modification and autophagy in cancer: roles, mechanisms, and therapeutic potential. [PDF]
Liu Y +5 more
europepmc +1 more source
Bakuchiol: From structural mimicry to systems‐level skin biology
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley +1 more source
Crystal structure of methanogen MtxX (Methanogen Marker Protein MMP4) from <i>Methanothermobacter thermautotrophicus</i> ΔH. [PDF]
Sutherland-Smith AJ +5 more
europepmc +1 more source
Genomic variation drives plant flavor diversification
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu +5 more
wiley +1 more source
Editorial: Mutualistic and antagonistic interactions in the human oral microbiome. [PDF]
Zhou W, Huang S, Huang X.
europepmc +1 more source
Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer +4 more
wiley +1 more source

