Results 1 to 10 of about 124,205 (336)

Lexicología y fonología históricas del Aché [PDF]

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas, 2015
En este artículo se identifican unos 200 lexemas del aché (familia Tupí-Guaraní) con sus cognados en 20 de las demás lenguas de la familia. Este rastreo lexicológico no sólo muestra que la base del léxico aché es fundamentalmente tupí-guaraní (TG ...
Wolf Dietrich
doaj   +2 more sources

El genocidio aché: de la protección internacional a la jurisdicción universal

Revista de Estudios sobre Genocidio, 2020
El genocidio aché es un caso paradigmático de exterminio de un pueblo indígena americano en el marco de procesos de colonización del siglo XX. Su tratamiento en el marco de los sistemas internacionales de protección de derechos humanos y en las medidas ...
Hugo Valiente
doaj   +1 more source

Inhibition of Muscle-Specific Protein Kinase (MuSK) Releases Organophosphate-Aged Acetylcholinesterase (AChE) from C2C12 Cells [PDF]

Toxics
Mechanistically, OPs inhibit acetylcholinesterase (AChE), an enzyme that terminates cholinergic transmission, triggering a sustained activation of acetylcholine receptors.
Monica Moncada-Restrepo, Sarah Eysoldt, Jeronimo Medina, Valentina Di Guida, Jeremy W. Chambers   +4 more
doaj   +2 more sources

Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A new series of tertiary amine derivatives of chlorochalcone (4a∼4l) were designed, synthesized and evaluated for the effect on acetylcholinesterase (AChE) and buthylcholinesterase (BuChE).
Xiao-hui Gao, Chao Zhou, Hao-ran Liu, Lin-bo Liu, Jing-jing Tang, Xin-hua Xia   +5 more
doaj   +2 more sources

Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

Pharmaceutics, 2022
One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the blood-brain barrier (BBB).
D. Kuznetsova, G. Gaynanova, E. Vasilieva, R. Pavlov, I. Zueva, V. Babaev, D. Kuznetsov, A. Voloshina, K. Petrov, L. Zakharova, O. Sinyashin   +10 more
semanticscholar   +1 more source

Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.

Journal of Medicinal Chemistry, 2021
Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer's disease (AD).
Hong Yao, G. Uras, Pengfei Zhang, Shengtao Xu, Ying‐Hao Yin, Jie Liu, S. Qin, Xinuo Li, S. Allen, Renren Bai, Qi Gong, Haiyan Zhang, Zheying Zhu, Jinyi Xu   +13 more
semanticscholar   +1 more source

TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish

Cells, 2021
The “distal axonopathy” hypothesis in amyotrophic lateral sclerosis (ALS) proposes that pathological changes occur at the neuromuscular junction (NMJ) early in the disease. While acetylcholinesterase (AChE) plays an important role in the functionality of
María-Letizia Campanari, A. Marian, S. Ciura, E. Kabashi   +3 more
semanticscholar   +1 more source

Seeking advice: A sampling approach to advice taking [PDF]

Judgment and Decision Making, 2016
The present research addresses advice taking from a holistic perspective covering both advice seeking and weighting. We build on previous theorizing that assumes that underweighting of advice results from biased samples of information.
Mandy Hütter, Fabian Ache
doaj   +2 more sources

Brain-wide mapping of c-fos expression in the single prolonged stress model and the effects of pretreatment with ACH-000029 or prazosin

Neurobiology of Stress, 2020
Post-traumatic stress disorder (PTSD) is a mental health condition that is triggered by a stressful event, with symptoms including exaggerated startle response, intrusive traumatic memories and nightmares.
Hatylas Azevedo, Marcos Ferreira, Alessandra Mascarello, Pavel Osten, Cristiano Ruch Werneck Guimarães   +4 more
doaj   +1 more source

MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy

Biomolecules, 2020
Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer’s disease (AD) development as its overexpression is directly linked to increased tau phosphorylation.
Anas Shamsi, Saleha Anwar, Taj Mohammad, M. Alajmi, A. Hussain, M. Rehman, G. Hasan, A. Islam, M. Hassan   +8 more
semanticscholar   +1 more source