Results 121 to 130 of about 64,209 (243)

Targeted acetylcholinesterase-responsive drug carriers with long duration of drug action and reduced hepatotoxicity

International Journal of Nanomedicine, 2019
Yulong Lin, Yalin Wang, Jie Lv, Nannan Wang, Jing Wang, Meng LiCollege of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, People’s Republic of ChinaPurpose: Acetylcholinesterase (AChE) plays a critical role in the ...
Lin Y, Wang Y, Lv J, Wang N, Wang J, Li M   +5 more
doaj  

EVALUACI 3N DEL EFECTO TRIPANOCIDA DEL VENENO DE CASCABEL (CROTALUS DURISSUS CUMANENSIS Y C. VEGANDRIS) SOBRE EL TRYPANOSOMA CRUZI EN CULTIVOS IN VITRO (MEDIO LIT) [PDF]

El inter\ue9s de realizar dicha investigaci\uf3n parte de lograr un m\ue9todo efectivo para disminuir la reproducci\uf3n del T. cruzi, el cual fue descubierto por el Dr. Carlos Chagas en el a\uf1o 1909.
Mogoll\uf3n Saldivia, Alexander A.
core  

Exploring the Impact of Polystyrene Microplastic Beads on Male Gonads of the Marine Mussel, Mytilus galloprovincialis

Environmental Toxicology, EarlyView.
ABSTRACT Plastic, with its remarkable versatility and numerous applications, has greatly benefited humanity. However, its extreme resistance to natural degradation means it persists in the environment for long periods, causing global environmental problems.
Teresa Chianese, Mariachiara Galati, Tiziana Cappello, Maria Maisano, Gennaro Lettieri, Carmela Marinaro, Marina Piscopo, Gianluca Fasciolo, Carlos Gravato, Gaetana Napolitano, Giulia Paolella, Annamaria Locascio, Rosaria Scudiero, Luigi Rosati   +13 more
wiley   +1 more source

Inflectional morphology restructuring in ache - discussing grammatical change and language contact in tupí-guaraní subgroup - 1

Boletim do Museu Paraense Emílio Goeldi. Ciências Humanas
This paper deals with mechanisms of grammatical change in Ache, focusing on inflection. Ache contains restricted functional morphology when compared to most Tupí-Guaraní languages.
Eva-Maria Rößler
doaj   +1 more source

Monitoramento da extração de areia nos municípios não pertencentes ao Zoneamento Ambiental Minerário do trecho paulista da várzea do rio Paraíba do Sul. [PDF]

, 2019
Remote sensing techniques can significantly contribute to environmental monitoring of the low cost mineral extraction of sand pits. This study aims to evaluate the increase of sand pits mining activity between the period of 2004 to 2009, in ...
RUDORFF, B. F. T., SILVA, G. B. S. da, SIMI, R.   +2 more
core  

Comprehensive Evaluation of Bisphenol A Toxicity Reveals Neurobehavioral, Metabolic, and Reproductive Impairments in Girardia tigrina

Environmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), a common industrial chemical used in plastics and consumer products, is increasingly detected in aquatic environments, raising serious concerns about its potential ecological impacts. This study evaluated the sublethal and acute toxic effects of BPA on the freshwater planarian Girardia tigrina, a recognized model for ...
Raquel de Jesus Selestrino, Felipe Schaly, Welligton Luciano Braguini   +2 more
wiley   +1 more source

Etonogestrel and Alzheimer's: A multi-scale computational approach to acetylcholinesterase inhibition

Next Materials
Background: This study explores Etonogestrel, a synthetic progestin used in hormonal contraceptives, as a potential Acetylcholinesterase (AChE) inhibitor for treating Alzheimer's disease.
Kunal Bhattacharya, Nongmaithem Randhoni Chanu, Pukar Khanal, Atanu Bhattacharjee, Manodeep Chakraborty, Dibyajyoti Das   +5 more
doaj   +1 more source

Oxidative Damage, Energy Imbalance, and Behavioral Disruptions in Girardia tigrina Exposed to Treated Sewage Effluents

Environmental Toxicology, EarlyView.
ABSTRACT This study assessed the ecotoxicological effects of treated sewage on the freshwater planarian Girardia tigrina, integrating biochemical, energetic, and behavioral biomarkers. Planarians were exposed for 48 h to different concentrations of treated sewage (12.5%, 25%, 50%, and 100%) and compared to controls using commercial water and water from
Renata M. P. Freitas, Pedro H. Carvalho, Daniela de Melo e Silva, Carlos Gravato   +3 more
wiley   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source

Metabolic engineering of adipose‐derived stem cell exosomes via arachidonic acid potentiates diabetic wound repair by orchestrating angiogenesis: A multi‐omics guided strategy

VIEW, EarlyView.
AA‐Exos promotes angiogenesis and accelerates diabetic wound healing by activating the PI3K/AKT/mTOR pathway. Abstract Diabetic wounds are common and challenging complications of diabetes, characterized by delayed healing and an increased risk of infection.
Yujiao Cai, Jinnan Wang, Yan Liu, Xiaoke Zhu, Zhanyuan Yuan, Weiling Li, Dehui Che, Dongsheng Cao   +7 more
wiley   +1 more source