Results 21 to 30 of about 113,265 (275)
Scientific Reports, 2017 The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular processes and linked to a variety of tumors.
Rafael M. Couñago +11 more
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Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
Molecules, 2019 Alzheimer’s disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory.
U. Acar Çevik +6 more
semanticscholar +1 more source
ACS Medicinal Chemistry Letters, 2018 Designing multitarget-directed ligands (MTDLs) is considered to be a promising approach to address complex and multifactorial maladies such as Alzheimer's disease (AD). The concurrent inhibition of the two crucial AD targets, glycogen synthase kinase-3β (
Xueyang Jiang +8 more
semanticscholar +1 more source
Revista do Instituto de Medicina Tropical de São Paulo, 2001 The interruption of vectorial transmission of Chagas disease in Venezuela is attributed to the combined effects of ongoing entomoepidemiological surveillance, ongoing house spraying with residual insecticides and the concurrent building and modification ...
Alberto ACHÉ, Alí J. MATOS
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Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
Molecules, 2019 Alzheimer’s disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life conditions are extremely difficult ...
Derya Osmaniye +7 more
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Dez traduções para o poema “No meio do caminho”, de Carlos Drummond de Andrade
Cadernos de Tradução, 2010 : Apparently simple, the poem “In the Middle of the Road”, written by Carlos Drummond de Andrade, in 1928, holds in much more than the monotony evoqued by the poet. This article intends to show, through an examination of the poem’s formal
Maria Graciema Aché de Andrade
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Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men
International Journal of Environmental Research and Public Health, 2019 Exposure to bisphenol A (BPA) has been shown to impact human sperm quality. The epigenetic mechanisms underlying the effect remain unknown. The acetylcholinesterase (ACHE) gene is a sperm-expressed gene encoding the acetylcholine hydrolyzing enzyme ...
Xiuxia Song +7 more
semanticscholar +1 more source
Neurobiology of Stress, 2020 Post-traumatic stress disorder (PTSD) is a mental health condition that is triggered by a stressful event, with symptoms including exaggerated startle response, intrusive traumatic memories and nightmares.
Hatylas Azevedo +4 more
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DNA barcoding reveals the mislabeling of fish in a popular tourist destination in Brazil [PDF]
PeerJ, 2017 The consumption of raw fish has increased considerably in the West, since it is said to be potentially healthier than processed fish (for containing omega 3 and 6, essential amino acids and vitamins). However this potential benefit, as well as the taste,
Clisten Fátima Staffen +6 more
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RSC Advances, 2018 Ligand-based and energy-optimized structure-based approaches were considered to obtain excellent candidates as AChE inhibitors. The known AChE inhibitors were utilized to develop a pharmacophore hypothesis, HPRRR and X-ray crystallographic structures of ...
S. Jana, Ankit Ganeshpurkar, S. Singh
semanticscholar +1 more source