Results 21 to 30 of about 114,912 (318)

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives

Molecules, 2019
Alzheimer’s disease (AD), one of the main causes of aged dementia, is a progressive and degenerative neurological disorder characterized by loss of cognition and memory.
U. Acar Çevik, B. Sağlık, Serkan Levent, Derya Osmaniye, Betül Kaya Çavuşoğlu, Yusuf Ozkay, Z. Kaplancıklı   +6 more
semanticscholar   +1 more source

Analysis of antenal sensilla patterns of Rhodnius prolixus from Colombia and Venezuela [PDF]

, 2005
Antennal sensilla patterns were used to analyze population variation of domestic Rhodnius prolixus from six departments and states representing three biogeographical regions of Colombia and Venezuela.
Aché A, Angulo VM, Añéz N, Carbajal de la Fuente AN, Catalá S, Catalá S, Catalá S, Catalá S, Catalá S, Corredor A, Dujardin JP, Dujardin JP, Esteban L, Feliciangeli MD, Gamboa CJ, Gracco M, Jaramillo C, Jaramillo N, Lyda Esteban, M Dora Feliciangeli, Molina JA, Monteiro FA, Monteiro FA, Rabinovich JE, Sandoval CM, Schofield CJ, Schofield CJ, Silvia Catalá, Sokal RR, Víctor Manuel Angulo, Zeledón R   +30 more
core   +4 more sources

El legado filosófico-político de Pierre Clastres

Cahiers d’Études Romanes, 2016
L’ethnologue français Pierre Clastres, accompagné des indiens Aché Guayajkí élabore sur les montagnes du Paraguay une réflexion sur la société sans État.
José Manuel Silvero
doaj   +1 more source

Biomonitoring of Acetylcholinesterase (AChE) Activity among Smallholder Horticultural Farmers Occupationally Exposed to Mixtures of Pesticides in Tanzania

Journal of Environmental and Public Health, 2019
Biomonitoring of pesticides exposure has currently become a matter of great public concern due to the potential health effects of pesticides. This study assessed levels of acetylcholinesterase (AChE) inhibition and associated health effects in ...
J. Kapeleka, E. Sauli, O. Sadik, P. Ndakidemi   +3 more
semanticscholar   +1 more source

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Scientific Reports, 2017
The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular processes and linked to a variety of tumors.
Rafael M. Couñago, Charles K. Allerston, Pavel Savitsky, Hatylas Azevedo, Paulo H. Godoi, Carrow I. Wells, Alessandra Mascarello, Fernando H. de Souza Gama, Katlin B. Massirer, William J. Zuercher, Cristiano R. W. Guimarães, Opher Gileadi   +11 more
doaj   +1 more source

Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these compounds exhibited strong and clearly selective inhibition to eeAChE.
Jie Fu, Fengqi Bao, M. Gu, Jing Liu, Zhipeng Zhang, Jiaoli Ding, Sai-Sai Xie, Jinsong Ding   +7 more
semanticscholar   +1 more source

Interrupting Chagas disease transmission in Venezuela A interrupção da transmissão da doença de Chagas na Venezuela

Revista do Instituto de Medicina Tropical de São Paulo, 2001
The interruption of vectorial transmission of Chagas disease in Venezuela is attributed to the combined effects of ongoing entomoepidemiological surveillance, ongoing house spraying with residual insecticides and the concurrent building and modification ...
Alberto ACHÉ, Alí J. MATOS
doaj   +1 more source

Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.

ACS Medicinal Chemistry Letters, 2018
Designing multitarget-directed ligands (MTDLs) is considered to be a promising approach to address complex and multifactorial maladies such as Alzheimer's disease (AD). The concurrent inhibition of the two crucial AD targets, glycogen synthase kinase-3β (
Xueyang Jiang, Tingkai Chen, Junting Zhou, Siyu He, Hongyu Yang, Yao Chen, Wei Qu, F. Feng, Haopeng Sun   +8 more
semanticscholar   +1 more source

Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives

Molecules, 2019
Alzheimer’s disease (AD) is the most common of the degenerative brain diseases and is described together with the impairment of cognitive function. Patients with AD lose the capability to code new memories, and life conditions are extremely difficult ...
Derya Osmaniye, B. Sağlık, U. Acar Çevik, Serkan Levent, Betül Kaya Çavuşoğlu, Y. Özkay, Z. Kaplancıklı, Gülhan Turan   +7 more
semanticscholar   +1 more source

Bisphenol A Exposure and Sperm ACHE Hydroxymethylation in Men

International Journal of Environmental Research and Public Health, 2019
Exposure to bisphenol A (BPA) has been shown to impact human sperm quality. The epigenetic mechanisms underlying the effect remain unknown. The acetylcholinesterase (ACHE) gene is a sperm-expressed gene encoding the acetylcholine hydrolyzing enzyme ...
Xiuxia Song, M. Miao, Xiaoyu Zhou, De-kun Li, Youping Tian, Hong Liang, Runsheng Li, W. Yuan   +7 more
semanticscholar   +1 more source